Department of Chemistry, 1-014 Center for Science and Technology, Syracuse University, Syracuse, NY 13244, USA.
Chem Commun (Camb). 2020 Sep 14;56(71):10281-10284. doi: 10.1039/d0cc03271a. Epub 2020 Jul 31.
The substrate promiscuity of an acyltransferase is leveraged to synthesize artificial lipoproteins bearing a non-canonical PTM (ncPTM). The non-canonical functionality of these lipoproteins results in a distinctive hysteretic assembly-absent from the canonical lipoproteins-and is used to prepare hybrid multiblock materials with precise and programmable patterns of amphiphilicity. This study demonstrates the promise of expanding the repertoire of PTMs for the development of nanomaterials with a unique assembly and function.
酰基转移酶的底物混杂性被利用来合成带有非典型翻译后修饰（ncPTM）的人工脂蛋白。这些脂蛋白的非典型功能导致了独特的滞后组装——这在典型的脂蛋白中是不存在的——并被用于制备具有精确和可编程两亲性模式的混合多嵌段材料。本研究证明了扩展 PTM 库的潜力，用于开发具有独特组装和功能的纳米材料。
