（+）-sinensilactam A、（+）-lingzhilactone B 和（-）-lingzhiol 的集体对映选择性全合成：苯乙烯的不同反应性。

Collective enantioselective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B and (-)-lingzhiol: divergent reactivity of styrene.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, P. R. China.

Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.

出版信息

Chem Commun (Camb). 2020 Aug 27;56(69):10066-10069. doi: 10.1039/d0cc04064a.

DOI:10.1039/d0cc04064a

PMID:32735006

Abstract

The collective total synthesis of (+)-sinensilactam A, (+)-lingzhilactone B, (+)-lingzhilactone C and (-)-lingzhiol has been accomplished from a common epoxide intermediate 9. Chemoselective epoxy opening with either an aryl or alkene moiety of styrene led to different carbon skeletons, which can be advanced to a divergent and concise total synthesis of four meroterpenoids.

摘要

（+）-sinensilactam A、（+）-lingzhilactone B、（+）-lingzhilactone C 和（-）-lingzhiol 的全合成已经从一个共同的环氧化物中间体 9 完成。通过与苯乙烯的芳基或烯烃部分的选择性环氧化打开，可以得到不同的碳骨架，这些碳骨架可以进一步转化为四个倍半萜类化合物的发散和简洁的全合成。