Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.
Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir, Morocco.
Genet Test Mol Biomarkers. 2020 Sep;24(9):592-599. doi: 10.1089/gtmb.2020.0073. Epub 2020 Jul 28.
The multifunctional cytokines of the tumor necrosis factor (TNF) family have been found to be involved in the promotion of inflammatory responses, and to play critical roles in the pathogenesis of inflammatory, autoimmune, and malignant diseases. The aim of the present study was to assess the associations among the , , and polymorphisms, and the breast cancer (BC) susceptibility in the Moroccan population. We conducted a case-control study, including 492 participants made up of 264 pathologically confirmed BC subjects, and 228 healthy women as controls. The samples were genotyped by means of polymerase chain reaction-restriction fragment length polymorphism analyses. The and polymorphisms were significantly associated with increased risk of BC for the AA genotype, while, the AG genotype of may offer a protective effect in this population. Haplotypic analyses showed that the GAA and AAG haplotypes increased the risk significantly for BC. Moreover, a significant association was observed between polymorphisms at the locus and the clinical profiles of the patients with regard to their estrogen-and progesterone-positive receptor status. These findings indicate that gene polymorphisms are linked with the risk of BC in the Moroccan population. Further studies implementing a larger sample size are needed to support our findings.
肿瘤坏死因子（TNF）家族的多功能细胞因子已被发现参与炎症反应的促进，并在炎症、自身免疫和恶性疾病的发病机制中发挥关键作用。本研究旨在评估 、 和 多态性与摩洛哥人群乳腺癌（BC）易感性之间的关联。
我们进行了一项病例对照研究，包括 492 名参与者，其中 264 名经病理证实为 BC 患者，228 名健康女性为对照。通过聚合酶链反应-限制性片段长度多态性分析对样本进行基因分型。 和 多态性与 BC 的 AA 基因型风险增加显著相关，而 的 AG 基因型可能在该人群中提供保护作用。单倍型分析表明，GAA 和 AAG 单倍型显著增加了 BC 的风险。此外，还观察到 基因座的多态性与患者的临床特征之间存在显著关联，包括雌激素和孕激素阳性受体状态。
这些发现表明， 基因多态性与摩洛哥人群的 BC 风险相关。需要进行更大样本量的研究来支持我们的发现。
