Department of Neurology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
PLoS One. 2020 Jul 31;15(7):e0236828. doi: 10.1371/journal.pone.0236828. eCollection 2020.
Idiopathic intracranial hypertension (IIH) mostly affects obese women in childbearing age, leading to frustrating headache and permanent visual impairment. The exact etiology of this condition is poorly understood, and the population at risk and clinical presentation seems to be homogeneous. However, little attention has been paid to the clinical features of IIH patients with anemia. We herein performed a retrospective observational study by using the data of patients with presumed IIH who were referred to the neurology department of Beijing Tongren Hospital from January 2014 to August 2019 to describe the clinical features and radiological findings in patients with IIH and anemia, and compared these with those without anemia. The patients were divided into two groups based on the presence of anemic diseases. Clinical data including demographic characteristics, clinical features, past medical history, laboratory and neuroradiological findings, diagnoses, treatments and prognosis of these patients were reviewed and compared in both the groups. A total of 153 patients with IIH were enrolled, which included 22 cases with anemia (mean age, 33.23±9.68 years; 19 [86.36%] female) and 131 cases without anemia (mean age 37.11±11.56 years; 97 [74.05%] female). In the anemia group, 19/22 cases had iron deficiency anemia and 3/22 had renal anemia. Compared with patients in the non-anemia group, IIH patients with anemia had a shorter disease course, and tended to present pulsatile tinnitus and transverse sinus stenosis (TSS), faster and better prognosis after treatments for correcting anemia and reducing intracranial pressure. Our findings highlighted the importance of obtaining full blood counts in IIH patients with subacute onset, and provided appropriate and prompt treatments if proven anemic in order to bring better outcomes.
特发性颅内高压（IIH）主要影响育龄肥胖女性，导致令人沮丧的头痛和永久性视力损害。这种疾病的确切病因尚未完全了解，风险人群和临床表现似乎是同质的。然而，人们对伴有贫血的 IIH 患者的临床特征关注甚少。我们在此通过使用 2014 年 1 月至 2019 年 8 月期间被转诊到北京同仁医院神经科的疑似 IIH 患者的数据进行了回顾性观察性研究，以描述伴有贫血的 IIH 患者的临床特征和影像学发现，并将其与不伴有贫血的患者进行比较。根据是否存在贫血性疾病，将患者分为两组。回顾并比较了两组患者的临床数据，包括人口统计学特征、临床特征、既往病史、实验室和神经影像学检查结果、诊断、治疗和预后。共纳入 153 例 IIH 患者，其中 22 例伴有贫血（平均年龄 33.23±9.68 岁；19 例[86.36%]为女性），131 例不伴有贫血（平均年龄 37.11±11.56 岁；97 例[74.05%]为女性）。在贫血组中，19/22 例为缺铁性贫血，3/22 例为肾性贫血。与非贫血组患者相比，贫血的 IIH 患者疾病病程更短，更倾向于出现搏动性耳鸣和横窦狭窄（TSS），在纠正贫血和降低颅内压治疗后，预后更快更好。我们的研究结果强调了在亚急性起病的 IIH 患者中获得全血细胞计数的重要性，如果证实存在贫血，应给予适当和及时的治疗，以获得更好的结果。
