The modulatory effect of plant polysaccharides on gut flora and the implication for neurodegenerative diseases from the perspective of the microbiota-gut-brain axis.

The microbiota-gut-brain axis includes a two-way communication pattern between the microorganisms that live in our gut and our brain function and behavior. Intestinal flora disorders not only induce related metabolic diseases, but also have an important relationship with neurodegenerative diseases. The present studies have shown that natural polysaccharides are important for maintaining the steady status of intestinal flora. This review aims to summarize the two-way relationship between the gut microbiota and the brain, and the modulatory effect of plant polysaccharides on gut flora, which provides new ideas for the prevention and treatment of the neurodegenerative diseases.