• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

神经退行性疾病中的脑-肠-骨轴：见解、挑战与未来展望。

The Brain-Gut-Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects.

机构信息

Department of Neurosurgery, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

Tongji University Cancer Center, Shanghai Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, 200092, China.

出版信息

Adv Sci (Weinh). 2024 Oct;11(38):e2307971. doi: 10.1002/advs.202307971. Epub 2024 Aug 9.

DOI:10.1002/advs.202307971
PMID:39120490
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11481201/
Abstract

Neurodegenerative diseases are global health challenges characterized by the progressive degeneration of nerve cells, leading to cognitive and motor impairments. The brain-gut-bone axis, a complex network that modulates multiple physiological systems, has gained increasing attention owing to its profound effects on the occurrence and development of neurodegenerative diseases. No comprehensive review has been conducted to clarify the triangular relationship involving the brain-gut-bone axis and its potential for innovative therapies for neurodegenerative disorders. In light of this, a new perspective is aimed to propose on the interplay between the brain, gut, and bone systems, highlighting the potential of their dynamic communication in neurodegenerative diseases, as they modulate multiple physiological systems, including the nervous, immune, endocrine, and metabolic systems. Therapeutic strategies for maintaining the balance of the axis, including brain health regulation, intestinal microbiota regulation, and improving skeletal health, are also explored. The intricate physiological interactions within the brain-gut-bone axis pose a challenge in the development of effective treatments that can comprehensively target this system. Furthermore, the safety of these treatments requires further evaluation. This review offers a novel insights and strategies for the prevention and treatment of neurodegenerative diseases, which have important implications for clinical practice and patient well-being.

摘要

神经退行性疾病是全球性的健康挑战，其特征是神经细胞的进行性退化，导致认知和运动障碍。脑-肠-骨轴是一个调节多个生理系统的复杂网络，由于其对神经退行性疾病的发生和发展有深远的影响，因此越来越受到关注。目前还没有全面的综述来阐明涉及脑-肠-骨轴的三角关系及其在神经退行性疾病创新治疗中的潜力。有鉴于此，本文旨在提出一个新的视角，探讨脑、肠和骨骼系统之间的相互作用，强调它们在调节包括神经、免疫、内分泌和代谢系统在内的多个生理系统中的动态通讯在神经退行性疾病中的潜在作用。还探讨了维持轴平衡的治疗策略，包括脑健康调节、肠道微生物群调节和改善骨骼健康。脑-肠-骨轴内错综复杂的生理相互作用给开发能够全面针对该系统的有效治疗方法带来了挑战。此外，这些治疗方法的安全性还需要进一步评估。本综述为神经退行性疾病的预防和治疗提供了新的见解和策略，对临床实践和患者福祉具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/0853a8f1c39a/ADVS-11-2307971-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/f05af1f305bb/ADVS-11-2307971-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/fcdd73e10c8c/ADVS-11-2307971-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/be5e5055a7fd/ADVS-11-2307971-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/b6d3d4d9dd90/ADVS-11-2307971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/e54a10afe1a2/ADVS-11-2307971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/9d9908ededf6/ADVS-11-2307971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/ac73965bdaa5/ADVS-11-2307971-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/a32ca078f10c/ADVS-11-2307971-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/bd2f062908f2/ADVS-11-2307971-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/f7bc0639531f/ADVS-11-2307971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/014090d2bd86/ADVS-11-2307971-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/0853a8f1c39a/ADVS-11-2307971-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/f05af1f305bb/ADVS-11-2307971-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/fcdd73e10c8c/ADVS-11-2307971-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/be5e5055a7fd/ADVS-11-2307971-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/b6d3d4d9dd90/ADVS-11-2307971-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/e54a10afe1a2/ADVS-11-2307971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/9d9908ededf6/ADVS-11-2307971-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/ac73965bdaa5/ADVS-11-2307971-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/a32ca078f10c/ADVS-11-2307971-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/bd2f062908f2/ADVS-11-2307971-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/f7bc0639531f/ADVS-11-2307971-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/014090d2bd86/ADVS-11-2307971-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6bd0/11481201/0853a8f1c39a/ADVS-11-2307971-g010.jpg

相似文献

1
The Brain-Gut-Bone Axis in Neurodegenerative Diseases: Insights, Challenges, and Future Prospects.神经退行性疾病中的脑-肠-骨轴：见解、挑战与未来展望。
Adv Sci (Weinh). 2024 Oct;11(38):e2307971. doi: 10.1002/advs.202307971. Epub 2024 Aug 9.
2
Gut microbiota: the indispensable player in neurodegenerative diseases.肠道微生物群：神经退行性疾病中不可或缺的角色。
J Sci Food Agric. 2024 Sep;104(12):7096-7108. doi: 10.1002/jsfa.13509. Epub 2024 Apr 23.
3
Immune-microbiome interplay and its implications in neurodegenerative disorders.免疫-微生物组相互作用及其在神经退行性疾病中的意义。
Metab Brain Dis. 2022 Jan;37(1):17-37. doi: 10.1007/s11011-021-00807-3. Epub 2021 Aug 6.
4
Bidirectional communication between mast cells and the gut-brain axis in neurodegenerative diseases: Avenues for therapeutic intervention.神经退行性疾病中肥大细胞与肠脑轴的双向通讯：治疗干预的途径。
Brain Res Bull. 2021 Jul;172:61-78. doi: 10.1016/j.brainresbull.2021.04.010. Epub 2021 Apr 20.
5
Deciphering the microbial map and its implications in the therapeutics of neurodegenerative disorder.解析微生物图谱及其在神经退行性疾病治疗中的意义。
Ageing Res Rev. 2024 Sep;100:102466. doi: 10.1016/j.arr.2024.102466. Epub 2024 Aug 27.
6
Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases.微生物群-肠-脑轴及其在神经退行性疾病中的治疗应用。
Signal Transduct Target Ther. 2024 Feb 16;9(1):37. doi: 10.1038/s41392-024-01743-1.
7
The connection between gut microbiota and its metabolites with neurodegenerative diseases in humans.肠道微生物群及其代谢物与人类神经退行性疾病之间的关系。
Metab Brain Dis. 2024 Jun;39(5):967-984. doi: 10.1007/s11011-024-01369-w. Epub 2024 Jun 7.
8
Exploring the gut-brain Axis: Potential therapeutic impact of Psychobiotics on mental health.探索肠脑轴：益生菌对心理健康的潜在治疗作用。
Prog Neuropsychopharmacol Biol Psychiatry. 2024 Aug 30;134:111073. doi: 10.1016/j.pnpbp.2024.111073. Epub 2024 Jun 22.
9
Probiotics and the microbiota-gut-brain axis in neurodegeneration: Beneficial effects and mechanistic insights.益生菌与神经退行性变中的肠脑轴菌群：有益作用和机制见解。
Life Sci. 2024 Aug 1;350:122748. doi: 10.1016/j.lfs.2024.122748. Epub 2024 Jun 4.
10
The modulatory effect of plant polysaccharides on gut flora and the implication for neurodegenerative diseases from the perspective of the microbiota-gut-brain axis.植物多糖对肠道菌群的调节作用及其对基于肠道菌群-肠-脑轴的神经退行性疾病的影响。
Int J Biol Macromol. 2020 Dec 1;164:1484-1492. doi: 10.1016/j.ijbiomac.2020.07.208. Epub 2020 Jul 29.

引用本文的文献

1
The altered hypothalamic network functional connectivity in diminished ovarian reserve and regulation effect of acupuncture: a randomized controlled neuroimaging study protocol.卵巢储备功能减退时下丘脑网络功能连接的改变及针刺的调节作用：一项随机对照神经影像学研究方案
Front Endocrinol (Lausanne). 2025 Aug 8;16:1598943. doi: 10.3389/fendo.2025.1598943. eCollection 2025.
2
Gut-Brain Interactions in Neuronal Ceroid Lipofuscinoses: A Systematic Review Beyond the Brain in Paediatric Dementias.神经元蜡样脂褐质沉积症中的肠-脑相互作用：小儿痴呆症中超越大脑的系统综述
Int J Mol Sci. 2025 Jul 25;26(15):7192. doi: 10.3390/ijms26157192.
3

本文引用的文献

1
The gut microbiome: an important role in neurodegenerative diseases and their therapeutic advances.肠道微生物组：在神经退行性疾病及其治疗进展中的重要作用。
Mol Cell Biochem. 2024 Sep;479(9):2217-2243. doi: 10.1007/s11010-023-04853-6. Epub 2023 Oct 3.
2
Causal Link between Gut Microbiota, Neurophysiological States, and Bone Diseases: A Comprehensive Mendelian Randomization Study.肠道微生物群、神经生理状态和骨骼疾病之间的因果关系：一项综合的孟德尔随机化研究。
Nutrients. 2023 Sep 11;15(18):3934. doi: 10.3390/nu15183934.
3
The role of Fecal Microbiota Transplantation (FMT) in treating patients with multiple sclerosis.
Modulatory Effects of on Neurodegenerative Diseases: Unveiling the Latest Findings and Applications Related to Neuroinflammation, Oxidative Stress, and Cognitive Dysfunction.
[具体物质名称]对神经退行性疾病的调节作用：揭示与神经炎症、氧化应激和认知功能障碍相关的最新发现及应用
Antioxidants (Basel). 2025 Jul 12;14(7):854. doi: 10.3390/antiox14070854.
4
Bidirectional Interaction Between the Brain and Bone in Traumatic Brain Injury.创伤性脑损伤中脑与骨的双向相互作用
Adv Sci (Weinh). 2025 Aug;12(31):e03149. doi: 10.1002/advs.202503149. Epub 2025 Jul 14.
5
Optimal dosage of group-based organized physical activity for enhancing social abilities in autistic children: insights from a multilevel meta-analysis.基于小组的有组织体育活动对提高自闭症儿童社交能力的最佳剂量：一项多层次荟萃分析的见解
Int J Behav Nutr Phys Act. 2025 Jul 1;22(1):87. doi: 10.1186/s12966-025-01787-8.
6
The potential link between the development of Alzheimer's disease and osteoporosis.阿尔茨海默病的发展与骨质疏松症之间的潜在联系。
Biogerontology. 2025 Jan 20;26(1):43. doi: 10.1007/s10522-024-10181-z.
7
Efficacy of probiotic, prebiotic, synbiotic and postbiotic supplementation on gastrointestinal health in cats: systematic review and meta-analysis.益生菌、益生元、合生元和后生元补充剂对猫胃肠道健康的功效：系统评价和荟萃分析
J Small Anim Pract. 2025 Apr;66(4):219-235. doi: 10.1111/jsap.13822. Epub 2025 Jan 12.
粪便微生物群移植（FMT）在治疗多发性硬化症患者中的作用。
Expert Rev Neurother. 2023 Jul-Dec;23(10):921-930. doi: 10.1080/14737175.2023.2250919. Epub 2023 Aug 24.
4
GV-971 attenuates α-Synuclein aggregation and related pathology.GV-971 可减轻 α-突触核蛋白聚集和相关病变。
CNS Neurosci Ther. 2024 Feb;30(2):e14393. doi: 10.1111/cns.14393. Epub 2023 Aug 10.
5
Distinct molecular profiles of skull bone marrow in health and neurological disorders.健康和神经紊乱状态下颅骨骨髓的独特分子特征。
Cell. 2023 Aug 17;186(17):3706-3725.e29. doi: 10.1016/j.cell.2023.07.009. Epub 2023 Aug 9.
6
Mechanism of action of gut microbiota and probiotic Lactobacillus rhamnosus GG on skeletal remodeling in mice.肠道微生物群和益生菌鼠李糖乳杆菌 GG 对小鼠骨骼重塑作用的机制。
Endocrinol Diabetes Metab. 2024 Jan;7(1):e440. doi: 10.1002/edm2.440. Epub 2023 Jul 28.
7
WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective.WNT-β连环蛋白信号通路作为神经退行性疾病的潜在治疗靶点：现状与未来展望
Diseases. 2023 Jun 25;11(3):89. doi: 10.3390/diseases11030089.
8
Crosstalk Between the Neuroendocrine System and Bone Homeostasis.神经内分泌系统与骨稳态的相互作用。
Endocr Rev. 2024 Jan 4;45(1):95-124. doi: 10.1210/endrev/bnad025.
9
Gut microbiota dysbiosis and Huntington's disease: Exploring the gut-brain axis and novel microbiota-based interventions.肠道微生物失调与亨廷顿病：探索肠道-大脑轴及基于微生物组的新干预措施。
Life Sci. 2023 Sep 1;328:121882. doi: 10.1016/j.lfs.2023.121882. Epub 2023 Jun 24.
10
The role of cellular and molecular neuroimmune crosstalk in gut immunity.细胞和分子神经免疫相互作用在肠道免疫中的作用。
Cell Mol Immunol. 2023 Nov;20(11):1259-1269. doi: 10.1038/s41423-023-01054-5. Epub 2023 Jun 19.