Sangster B, Zimmerman A N, van Heijst A N
Acta Pharmacol Toxicol (Copenh). 1979 Feb;44(2):139-45. doi: 10.1111/j.1600-0773.1979.tb02308.x.
Biperiden lactate was administered intravenously in overdose to dogs under general anaesthesia. Biperiden appeared to have a toxic influence on respiration and circulation independently. Respiratory arrest occurred at a dose of 33 +/- 10 mg/kg and has probably a central origin. When artificial ventilation was instituted circulatory standstill occurred at a dose of 45 +/- 5 mg/kg. The toxic influence of biperiden is characterised by a decrease of heart rate and of left ventricular contractility resulting in cardiogenic shock. Biperiden is compared with orphenadrine as far as its potential hazard is concerned for patients trying to commit suicide by ingesting an overdose.
在全身麻醉下，给犬静脉注射过量的乳酸苯海索。苯海索似乎对呼吸和循环有独立的毒性影响。呼吸停止发生在剂量为33±10毫克/千克时，可能起源于中枢。当进行人工通气时，循环停止发生在剂量为45±5毫克/千克时。苯海索的毒性影响表现为心率和左心室收缩力降低，导致心源性休克。就试图过量服药自杀的患者而言，将苯海索与邻甲苯海明的潜在危害进行了比较。
