Sangster B, Nieuwland G, Zimmerman A N, Van Heijst A N
Toxicol Eur Res. 1979 Mar;2(2):93-7.
Orphenadrine HCL was intravenously administered to rats under urethane anesthesia to investigate whether the primary cause of death in orphenadrine intoxication is respiratory arrest or cardiac standstill. The spontaneously breathing animals died from apnoe after a mean dose of 63 + 11 mg/kg. The artificially ventilated animals died from cardiac arrest after a mean dose of 144 +/- 47 mg/kg. It was concluded that primary cause of death is respiratory insufficiency and that hypoventilation can mask the cardiotoxicity of orphenadrine. On the analogy of earlier experiments in dogs the ability of droperidol to counteract the influence of orphenadrine was investigated. Droperidol enhanced the influence of orphenadrine on respiration and had no influence on the cardiotoxic influence of orphenadrine in the rat.
在乌拉坦麻醉下给大鼠静脉注射盐酸奥芬那君，以研究奥芬那君中毒致死的主要原因是呼吸骤停还是心脏停搏。自主呼吸的动物在平均剂量为63±11mg/kg后死于呼吸暂停。人工通气的动物在平均剂量为144±47mg/kg后死于心脏骤停。得出的结论是，死亡的主要原因是呼吸功能不全，通气不足可掩盖奥芬那君的心脏毒性。根据早期在狗身上进行的实验，研究了氟哌利多对抗奥芬那君影响的能力。氟哌利多增强了奥芬那君对呼吸的影响，对大鼠奥芬那君的心脏毒性影响没有作用。
