Daci Armond, Celik Zeynep, Ozen Gulsev, Dashwood Michael, Dogan B Sonmez Uydes, Topal Gokce
Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey; Department of Pharmacy, Faculty of Medicine, University of Prishtina, Prishtina, Kosovo.
Department of Pharmacology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Eur J Pharm Sci. 2020 Oct 1;153:105499. doi: 10.1016/j.ejps.2020.105499. Epub 2020 Jul 28.
Omega-3 polyunsaturated fatty acids (n-3 PUFAs), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are mainly found in marine fish oils and commercially available fish oil supplements. Several studies have documented that n-3 PUFAs can reduce the risk of cardiovascular diseases through anti-inflammatory, anti-thrombotic, and anti-atherosclerotic properties. Notably, regulation of vascular tone is one of the most important bases of cardiovascular health and especially for maintaining blood pressure within optimal physiological ranges. Recent clinical and animal studies indicate an association between n-3 PUFAs and vascular functions. In this regard, many clinical trials and basic experimental studies have been conducted so far to investigate the influence of n-3 PUFAs on vascular tone. In this review, we have summarized the results obtained from both clinical and basic studies that evaluated the effect of n-3 PUFAs under physiological and pathological conditions. Moreover, we also focus on verifying the underlying basic molecular mechanism of n-3 PUFAs on the vascular system.
ω-3多不饱和脂肪酸（n-3 PUFAs），包括二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），主要存在于海洋鱼油和市售的鱼油补充剂中。多项研究表明，n-3 PUFAs可通过抗炎、抗血栓形成和抗动脉粥样硬化特性降低心血管疾病风险。值得注意的是，血管张力的调节是心血管健康的最重要基础之一，尤其是对于将血压维持在最佳生理范围内而言。最近的临床和动物研究表明n-3 PUFAs与血管功能之间存在关联。在这方面，迄今为止已经进行了许多临床试验和基础实验研究，以探究n-3 PUFAs对血管张力的影响。在本综述中，我们总结了在生理和病理条件下评估n-3 PUFAs作用的临床和基础研究结果。此外，我们还着重验证n-3 PUFAs对血管系统作用的潜在基础分子机制。
