Instituto de Fisiología Celular. Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, DF, 04510, Mexico.
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA, 98195, USA.
Cell Calcium. 2020 Nov;91:102258. doi: 10.1016/j.ceca.2020.102258. Epub 2020 Jul 24.
Ion channels are transmembrane proteins whose canonical function is the transport of ions across the plasma membrane to regulate cell membrane potential and play an essential role in neural communication, nerve conduction, and muscle contraction. However, over the last few years, non-canonical functions have been identified for many channels, having active roles in phagocytosis, invasiveness, proliferation, among others. The participation of some channels in cell proliferation has raised the question of whether they may play an active role in mitosis. There are several reports showing the participation of channels during interphase, however, the direct participation of ion channels in mitosis has received less attention. In this article, we summarize the current evidence on the participation of ion channels in mitosis. We also summarize some tools that would allow the study of ion channels and cell cycle regulatory molecules in individual cells during mitosis.
离子通道是跨膜蛋白，其典型功能是将离子穿过质膜运输，以调节细胞膜电位，并在神经通讯、神经传导和肌肉收缩中发挥重要作用。然而，在过去的几年中，许多通道的非典型功能已被确定，它们在吞噬作用、侵袭、增殖等方面发挥着积极作用。一些通道参与细胞增殖的问题引发了它们是否可能在有丝分裂中发挥积极作用的疑问。有几项报道显示通道在间期中的参与，然而，离子通道在有丝分裂中的直接参与受到的关注较少。本文总结了目前关于离子通道参与有丝分裂的证据。我们还总结了一些工具，这些工具将允许在有丝分裂期间研究单个细胞中的离子通道和细胞周期调节分子。
