Guangzhou Center for Disease Control and Prevention, Guangzhou, China.
Division of Medical Psychology and Behavioral Sciences, Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
J Affect Disord. 2020 Nov 1;276:732-737. doi: 10.1016/j.jad.2020.07.090. Epub 2020 Jul 24.
Understanding the contribution of childhood neighborhood quality (CNQ) and childhood friendship (CF) to the development of depressive symptoms during adulthood among the general population is of great importance to public health. This study aims to examine the longitudinal associations of CNQ and CF with the risk of later-life depressive symptoms in a representative Chinese population.
The data were from the China Health and Retirement Longitudinal Study (CHARLS). Depressive symptom score was measured by the 10-item Center for Epidemiological Studies-Depression Scale (CES-D10). CNQ and CF were measured by a standardized questionnaire.
A total of 13,354 individuals were included in our study. The participants with higher CNQ had a significantly low risk of depressive symptoms than those with lower CNQ score (OR=0.93, 95%CI: 0.92-0.93, P<0.001), and the association remained significant (OR=0.93, 95%CI: 0.91-0.95, P<0.001) after further adjustment for covariates. The participants with a higher CF score had a significantly low risk of depresssive symptoms than those with a lower CF score (adjusted OR=0.97, 95%CI: 0.96-0.98, P<0.001). Moreover, the associations of CNQ and CF score with the risk of depressive symptoms were significantly modulated by education level (both P<0.001), which means that high education level enlarged the inverse associations of CNQ/CF with depressive symptoms.
Higher CHQ and CF score are significantly associated with the lower risk of depressive symptoms in adulthood. Education attainment may mediate the associations of CNQ and CF with the risk of depressive symptoms.
了解童年邻里质量（CNQ）和童年友谊（CF）对普通人群成年后抑郁症状发展的贡献，对公共卫生具有重要意义。本研究旨在检验代表性中国人群中 CNQ 和 CF 与晚年抑郁症状风险的纵向关联。
数据来自中国健康与退休纵向研究（CHARLS）。抑郁症状评分采用 10 项流行病学研究中心抑郁量表（CES-D10）进行测量。CNQ 和 CF 通过标准化问卷进行测量。
共有 13354 人纳入本研究。CNQ 较高的参与者患抑郁症状的风险明显低于 CNQ 得分较低的参与者（OR=0.93，95%CI：0.92-0.93，P<0.001），且在进一步调整协变量后，该关联仍然显著（OR=0.93，95%CI：0.91-0.95，P<0.001）。CF 得分较高的参与者患抑郁症状的风险明显低于 CF 得分较低的参与者（调整后的 OR=0.97，95%CI：0.96-0.98，P<0.001）。此外，CNQ 和 CF 得分与抑郁症状风险的关联受到教育水平的显著调节（均 P<0.001），这意味着较高的教育水平扩大了 CNQ/CF 与抑郁症状之间的负向关联。
较高的 CHQ 和 CF 得分与成年后抑郁症状风险较低显著相关。教育程度可能调节 CNQ 和 CF 与抑郁症状风险之间的关联。
