Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
Acta Neurol Belg. 2021 Dec;121(6):1649-1659. doi: 10.1007/s13760-020-01455-7. Epub 2020 Jul 31.
To compare the clinical, imaging, and prognostic characteristics of AQP4 antibody-related diseases and MOG antibody-related diseases. The clinical data of 56 AQP4 antibody-positive patients and 14 MOG antibody-positive patients in the Second Xiangya Hospital of Central South University from June 2016 to June 2019 were collected. 92.9% of the patients with positive AQP4 antibody were females and 64.3% of patients with positive MOG antibody were females (P = 0.004). Patients with positive AQP4 antibody were more likely to have limb movement (P < 0.001) or limb sensory dysfunction (P < 0.001), and were more likely to have limb twitching (P = 0.036). In addition, AQP4 antibody-positive patients were more likely to have positive ANA (P = 0.013) and SSA antibody (P = 0.029), Ro-52 antibody (P = 0.047), immunoglobulin (P = 0.007), thyroid antibody (P = 0.007), abnormal C3 (P = 0.011), abnormal C4 (P = 0.014) than MOG antibody-positive patients. The involvement rate of head in MOG antibody-positive patients was higher than AQP4 antibody-positive patients (P = 0.029). The severity of clinical symptoms in AQP4-positive patients was usually more serious than that in MOG-positive patients (P < 0.001). The residual neurological deficit after treatment in AQP4-positive group was usually more serious than that in MOG-positive group (P < 0.001). AQP4 antibody-positive patients had a higher prevalence in women than MOG antibody-positive patients, and AQP4 antibody-positive patients were more likely to have spinal cord involvement symptoms and connective tissue antibody abnormalities. The EDSS score of them were higher than that of MOG antibody-positive patients after treatment, and the prognosis was worse.
比较水通道蛋白 4 抗体相关疾病和髓鞘少突胶质细胞糖蛋白抗体相关疾病的临床、影像学和预后特征。收集了 2016 年 6 月至 2019 年 6 月中南大学湘雅二医院 56 例水通道蛋白 4 抗体阳性患者和 14 例髓鞘少突胶质细胞糖蛋白抗体阳性患者的临床资料。水通道蛋白 4 抗体阳性患者中，92.9%为女性，髓鞘少突胶质细胞糖蛋白抗体阳性患者中，64.3%为女性（P=0.004）。水通道蛋白 4 抗体阳性患者更易出现肢体运动（P<0.001）或肢体感觉障碍（P<0.001），更易出现肢体抽搐（P=0.036）。此外，水通道蛋白 4 抗体阳性患者更易出现抗核抗体阳性（P=0.013）和抗 SSA 抗体阳性（P=0.029）、Ro-52 抗体阳性（P=0.047）、免疫球蛋白阳性（P=0.007）、甲状腺抗体阳性（P=0.007）、C3 异常（P=0.011）、C4 异常（P=0.014），而髓鞘少突胶质细胞糖蛋白抗体阳性患者更易出现头部受累（P=0.029）。水通道蛋白 4 抗体阳性患者的临床症状严重程度通常较髓鞘少突胶质细胞糖蛋白抗体阳性患者严重（P<0.001）。治疗后水通道蛋白 4 抗体阳性组的神经功能缺损残留通常较髓鞘少突胶质细胞糖蛋白抗体阳性组严重（P<0.001）。水通道蛋白 4 抗体阳性患者在女性中的患病率高于髓鞘少突胶质细胞糖蛋白抗体阳性患者，且水通道蛋白 4 抗体阳性患者更易出现脊髓受累症状和结缔组织抗体异常。治疗后，水通道蛋白 4 抗体阳性患者的 EDSS 评分高于髓鞘少突胶质细胞糖蛋白抗体阳性患者，预后较差。
