Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, United Kingdom; Cardiff University, Cardiff, United Kingdom.
Int Rev Neurobiol. 2020;154:325-344. doi: 10.1016/bs.irn.2020.03.017. Epub 2020 Jul 24.
Alzheimer's disease is characterized by aggregated amyloid beta plaques and neurofibrillary tangles. Apart from the plaques and tangles, microglial activation plays a significant role in neurodegeneration and neuronal function. This review discusses the way in which microglial activation influences neurodegeneration and how systemic inflammation, type 2 diabetes mellitus, obesity and hypercholesterolemia influence neuroinflammation. Also reviewed is how systemic inflammation influences microglial activation along with the relationship between microglial activation and glucose metabolism.
阿尔茨海默病的特征是淀粉样β斑块和神经原纤维缠结的聚集。除了斑块和缠结外，小胶质细胞激活在神经退行性变和神经元功能中起着重要作用。这篇综述讨论了小胶质细胞激活如何影响神经退行性变，以及系统性炎症、2 型糖尿病、肥胖和高胆固醇血症如何影响神经炎症。还回顾了系统性炎症如何影响小胶质细胞激活以及小胶质细胞激活与葡萄糖代谢之间的关系。
