Institute for Clinical Chemistry and Laboratory Medicine, University Clinic Carl Gustav Carus, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany.
Cells. 2021 Jun 23;10(7):1584. doi: 10.3390/cells10071584.
Increased life expectancy in combination with modern life style and high prevalence of obesity are important risk factors for development of neurodegenerative diseases. Neuroinflammation is a feature of neurodegenerative diseases, and microglia, the innate immune cells of the brain, are central players in it. The present review discusses the effects of obesity, chronic peripheral inflammation and obesity-associated metabolic and endocrine perturbations, including insulin resistance, dyslipidemia and increased glucocorticoid levels, on microglial function.
预期寿命的延长，加上现代生活方式和肥胖症的高发，是神经退行性疾病发展的重要危险因素。神经炎症是神经退行性疾病的一个特征，而小胶质细胞是大脑的固有免疫细胞，是其中的核心参与者。本综述讨论了肥胖、慢性外周炎症以及肥胖相关的代谢和内分泌紊乱（包括胰岛素抵抗、血脂异常和皮质醇水平升高）对小胶质细胞功能的影响。
