Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Rome, Italy.
Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Rome, Italy.
Clin Neurol Neurosurg. 2020 Nov;198:106105. doi: 10.1016/j.clineuro.2020.106105. Epub 2020 Jul 24.
Contrast-enhanced ultrasound (CEUS) is a real-time, feasible technique. Both intraoperatively and bedside, it satisfies the need for serial assessment and easy performability. Initially employed in neuro-oncology, it has recently overcome this first application. We aimed to evaluate the literature and give a comprehensive view of its use in the fields listed below. A systematic review of all pertinent literature was performed via PubMed access according PRISMA P guidelines. Studies not involving human adults and not reporting original data were excluded. Cross-check of references of selected articles was performed to complete bibliographical research. 67 articles were then grouped by field of application: Oncology (26 articles) further subdivided in a) cranial tumors (23 articles) and b) spinal tumors (3 articles); Vascular (31 articles), divided in three sections: a) aneurysms, AVMs and AVFs surgery (6 articles), b) cerebral perfusion assessment and acute stroke patients management (15 articles), c) carotid plaques treatment (10 articles); TBI (2 articles); Pediatrics (4 articles); Peripheral nerve surgery (2 articles) and others (2 articles). CEUS versatility across the aforementioned areas was analyzed, underlining its complementarity to other well-settled imaging techniques. This review is focused on reporting CEUS advantages and disadvantages, suggesting a further broadening of the already numerous applications.
超声造影（CEUS）是一种实时、可行的技术。它在手术中和床边都满足了连续评估和易于操作的需求。最初应用于神经肿瘤学，最近已经超越了这一最初的应用。我们旨在评估文献，并对其在以下列出的领域中的应用进行全面的了解。通过 PubMed 访问，根据 PRISMA P 指南进行了所有相关文献的系统回顾。排除了不涉及人类成年人和未报告原始数据的研究。对选定文章的参考文献进行交叉核对，以完成文献研究。然后，将 67 篇文章按应用领域分组：肿瘤学（26 篇）进一步细分为 a）颅肿瘤（23 篇）和 b）脊柱肿瘤（3 篇）；血管（31 篇），分为三个部分：a）动脉瘤、动静脉畸形和动静脉瘘手术（6 篇），b）脑灌注评估和急性脑卒中患者管理（15 篇），c）颈动脉斑块治疗（10 篇）；创伤性脑损伤（2 篇）；儿科（4 篇）；周围神经外科（2 篇）和其他（2 篇）。分析了 CEUS 在上述领域的多功能性，强调了其对其他成熟成像技术的补充性。本综述重点介绍了 CEUS 的优缺点，建议进一步拓宽已经为数众多的应用。
