Mane Maya B, Bhandari Vinay M, Balapure Kshama, Ranade Vivek V
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NCL Pune, India.
Chemical Engineering and Process Development Division, CSIR-National Chemical Laboratory, Pune, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-NCL Pune, India.
Ultrason Sonochem. 2020 Dec;69:105272. doi: 10.1016/j.ultsonch.2020.105272. Epub 2020 Jul 24.
The present study reports, for the first time, a new and techno-economic strategy for effective removal of antimicrobial resistant bacteria (AMR) and difficult, opportunistic pathogen using cavitation and natural oils/plant extract. A hybrid methodology using natural oils of known health benefits has been discussed in combination with conventional physico-chemical method of hydrodynamic cavitation that not only provides efficient and effective water disinfection, but also eliminates harmful effects of conventional methods such as formation of disinfection by-products apart from reducing cost of treatment. A proof-of concept is demonstrated by achieving exceptionally high rates for practically complete removal of antimicrobial resistant (AMR) and relatively less researched, gram-negative opportunistic pathogen, Pseudomonas aeruginosa and gram-positive methicillin resistant, Staphylococcus aureus using a natural oil-Peppermint oil and two different cavitating reactors employing vortex flow (vortex diode) and linear flow (orifice) for hydrodynamic cavitation. >99% disinfection could be obtained, typically in less than 10 min, using vortex diode with operating pressure drop of 1 bar and low dose of 0.1% peppermint oil as an additive, depicting very high rates of disinfection. The rate of disinfection can be further increased by using simple aeration which can result in significant lowering of oil dose. The conventional device, orifice requires relatively higher pressure drop of 2 bar and comparatively more time (~20 min) for disinfection. The cost of the disinfection was also found to be significantly lower compared to most conventional processes indicating techno-economic feasibility in employing the developed hybrid method of disinfection for effectively eliminating bacteria including AMR bacteria from water. The developed approach not only highlights importance of going back to nature for not just conventional water disinfection, but also for eliminating hazardous AMR bacteria and may also find utility in many other applications for the removal of antimicrobial bacteria.
本研究首次报告了一种新的技术经济策略，该策略利用空化作用和天然油/植物提取物有效去除抗微生物耐药菌（AMR）以及难处理的机会致病菌。本文讨论了一种将具有已知健康益处的天然油与传统的流体动力空化物理化学方法相结合的混合方法，该方法不仅能提供高效的水消毒效果，还能消除传统方法的有害影响，如消毒副产物的形成，同时降低处理成本。通过使用天然油——薄荷油，以及两个分别采用涡旋流（涡旋二极管）和线性流（孔板）进行流体动力空化的不同空化反应器，实现了对抗微生物耐药菌以及研究相对较少的革兰氏阴性机会致病菌铜绿假单胞菌和革兰氏阳性耐甲氧西林金黄色葡萄球菌的几乎完全去除，从而证明了该概念验证。使用操作压降为1巴的涡旋二极管和低剂量0.1%的薄荷油作为添加剂，通常在不到10分钟内即可实现>99%的消毒率，消毒速率非常高。通过简单曝气可进一步提高消毒速率，这会显著降低油剂量。传统装置孔板需要相对较高的2巴压降和相对较长的消毒时间（约20分钟）。与大多数传统工艺相比，还发现该消毒成本显著更低，这表明采用所开发的混合消毒方法从水中有效去除包括抗微生物耐药菌在内的细菌在技术经济上是可行的。所开发的方法不仅凸显了回归自然对于传统水消毒以及消除有害抗微生物耐药菌的重要性，还可能在许多其他去除抗微生物细菌的应用中发挥作用。
