Endocrinology Division, Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255, 9° andar - Setor 9, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil; Neuroendocrinology Division, Instituto Estadual do Cérebro Paulo Niemeyer, 156th Resende Street, Rio de Janeiro, RJ, Brazil; Endocrinology Division, Hospital Federal de Bonsucesso, Rio de Janeiro, Brazil.
Endocrinology Division, Neuroendocrinology Research Center, Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255, 9° andar - Setor 9, Ilha do Fundão, Rio de Janeiro 21941-913, Brazil.
Endocrinol Metab Clin North Am. 2020 Sep;49(3):475-486. doi: 10.1016/j.ecl.2020.05.007. Epub 2020 Jul 15.
Acromegaly is a systemic disease associated with great morbidity and increased mortality if not adequately treated. In the past decades much improvement has been achieved in its treatment and in the knowledge of its comorbidities. We provide an update of acromegaly management with current recommendations. We also address long-term comorbidities emphasizing the changing face of the disease in more recent series, with a decrease of cardiovascular disease severity and an increased awareness of comorbidities like bone disease, manifested mainly as vertebral fractures and the change in the main cause of death (from cardiovascular disease to cancer in more recent series).
肢端肥大症是一种全身性疾病，如果治疗不充分，会导致很高的发病率和死亡率。在过去的几十年中，其治疗方法和合并症的认识已经取得了很大的进展。我们提供了肢端肥大症管理的最新建议。我们还讨论了长期合并症，强调了最近的系列研究中疾病的变化，心血管疾病的严重程度降低，对合并症的认识增加，如骨疾病，主要表现为椎体骨折，以及主要死因的变化（从心血管疾病到最近系列中的癌症）。
