Padala Sandeep A, Medepalli Vidya M, Mohammed Azeem, Nahman Stanley
Nephrology, Augusta University Medical College of Georgia, Augusta, USA.
Medicine, Augusta University Medical College of Georgia, Augusta, USA.
Cureus. 2020 Jun 29;12(6):e8911. doi: 10.7759/cureus.8911.
Drug-induced autoimmunity occurs when exposure to a causative agent leads to serologic or clinical autoimmune responses. Syndromes that may be associated with drug-induced autoimmunity include antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and drug-induced lupus (DIL). When drug-induced autoimmunity involves the kidney, histological patterns of injury include pauci-immune glomerulonephritis (GN), which occurs with AAV, and immune complex-mediated GN, which is associated with DIL. We present a case of hydralazine-induced dual ANCA-positive vasculitis and nephritis.
药物性自身免疫是指接触致病因子后引发血清学或临床自身免疫反应。可能与药物性自身免疫相关的综合征包括抗中性粒细胞胞浆抗体（ANCA）相关性血管炎（AAV）和药物性狼疮（DIL）。当药物性自身免疫累及肾脏时，损伤的组织学模式包括AAV相关的寡免疫性肾小球肾炎（GN）和DIL相关的免疫复合物介导的GN。我们报告一例肼屈嗪诱导的双ANCA阳性血管炎和肾炎病例。
