前列腺腺癌放疗后发生的放射性肉瘤。
Radiation-induced sarcoma after radiation therapy for prostate adenocarcinoma.
作者信息
Wakabayashi Kohei, Konishi Kenta, Komatsu Tetsuya, Ishiba Ryo, Ota Naofumi, Ito Toshiki, Aki Ryota, Tsuchida Takashi, Miyake Hideaki, Nakamura Katsumasa
机构信息
Department of Radiation Oncology Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan.
Department of Urology Hamamatsu University School of Medicine Hamamatsu Shizuoka Japan.
出版信息
IJU Case Rep. 2019 Feb 24;2(2):98-101. doi: 10.1002/iju5.12052. eCollection 2019 Mar.
INTRODUCTION
Radiation therapy is widely used for prostate cancer, but radiation-induced sarcomas have been rarely reported.
CASE PRESENTATION
A 77-year-old Japanese male was diagnosed with prostate cancer and received a combined androgen blockade and radiation therapy (total dose of 76 Gy). Five years after the radiation therapy, testicular pain and dysuria appeared. Computed tomography showed a soft tissue dense mass with invasion to the right subpubic ramus and prostate, mainly to the perineum. A needle biopsy revealed the pathological features of high-grade sarcoma. The patient was diagnosed with radiation-induced sarcoma based on the cancer's occurrence in the vicinity of the radiation field.
CONCLUSION
Although irradiation is one of the important treatments for prostate cancer, the risk of radiation-induced malignancy should be considered.
引言
放射治疗广泛应用于前列腺癌，但辐射诱发的肉瘤鲜有报道。
病例报告
一名77岁的日本男性被诊断为前列腺癌，并接受了雄激素阻断联合放射治疗（总剂量76 Gy）。放射治疗五年后，出现睾丸疼痛和排尿困难。计算机断层扫描显示一个软组织密度肿块，侵犯右侧耻骨下支和前列腺，主要累及会阴。针吸活检显示为高级别肉瘤的病理特征。根据肿瘤在放射野附近发生，该患者被诊断为辐射诱发的肉瘤。
结论
尽管放射治疗是前列腺癌的重要治疗方法之一，但应考虑辐射诱发恶性肿瘤的风险。
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