Moritoki Yoshinobu, Mizuno Kentaro, Kato Taiki, Hamamoto Shuzo, Hattori Hideo, Ito Yasuhiko, Saitoh Shinji, Yasui Takahiro, Hayashi Yutaro
Department of Nephro-urology Nagoya City University Graduate School of Medical Sciences Nagoya Japan.
Department of Urology Anjo Kosei Hospital Anjo Japan.
IJU Case Rep. 2019 Mar 2;2(3):115-117. doi: 10.1002/iju5.12050. eCollection 2019 May.
Prepubertal testicular tumors can be both benign and malignant. Although most testicular teratomas are benign, some immature cases include malignant transformation or the mixed type with yolk sac tumor and, occasionally, it is challenging to rule out malignancy.
We present a case of immature testicular teratoma in a 7-month-old infant, whose alpha-fetoprotein level was sequentially elevated following orchidectomy. Since malignancy could not be ruled out, we performed whole body imaging and in-depth pathological exploration. GLYPICAN3, OCT3/4, and SOX2 staining revealed no evidence of malignancy. The patient was finally diagnosed with benign immature teratoma, and has been free from recurrence for 3 years.
Here, we describe the case report, as well as all the comprehensive diagnostic tests that we performed in order to rule out the malignant component.
青春期前睾丸肿瘤可分为良性和恶性。虽然大多数睾丸畸胎瘤是良性的，但一些不成熟的病例包括恶性转化或伴有卵黄囊瘤的混合型，偶尔排除恶性肿瘤具有挑战性。
我们报告一例7个月大婴儿的不成熟睾丸畸胎瘤，其甲胎蛋白水平在睾丸切除术后持续升高。由于不能排除恶性肿瘤，我们进行了全身成像和深入的病理检查。GLYPICAN3、OCT3/4和SOX2染色未发现恶性证据。该患者最终被诊断为良性不成熟畸胎瘤，至今已3年无复发。
在此，我们描述该病例报告以及为排除恶性成分而进行的所有综合诊断测试。
