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婴儿睾丸内青春期前型成熟畸胎瘤:一例报告及文献综述

Intratesticular prepubertal‑type mature teratoma in an infant: A case report and mini‑review of the literature.

作者信息

Fakhralddin Saman S, Ali Rawa M, Omar Sami Saleem, Ali Rebaz M, Mohammed Bryar O, Karim Rawa Amin, Abdullah Hiwa O, Mohammed Karukh K, Mohammed Shvan H, Ahmed Sasan M, Kakamad Fahmi H

机构信息

College of Medicine, University of Sulaimani, Sulaymaniyah, Kurdistan 46001, Iraq.

Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah, Kurdistan 46001, Iraq.

出版信息

Med Int (Lond). 2024 Jul 15;4(5):53. doi: 10.3892/mi.2024.177. eCollection 2024 Sep-Oct.

DOI:10.3892/mi.2024.177
PMID:39070002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273244/
Abstract

Testicular tumors are rare in children, representing a small percentage of pediatric solid tumors, with an incidence of 2 cases per 100,000 males. Teratomas, which are the most prevalent tumors in infants, may manifest in mature, immature, or malignant forms. While mature teratomas are typically found in the abdomen, intratesticular prepubertal-type teratomas in infants are infrequent. The present study describes the case of an infant with an intratesticular mature teratoma. A 6-month-old male infant presented with right-sided scrotal swelling, which was noted by his parents. There was no family history of similar conditions, and an investigation of his medical history did not reveal any notable findings. A physical examination revealed a non-reducible, solid mass indistinguishable from the right testicle, with no signs of inflammation or systemic symptoms. A scrotal sonography confirmed a large intratesticular cyst. The levels of α-fetoprotein and β-human chorionic gonadotropin were normal. Surgical tumor enucleation was performed, and the histopathological examination revealed a benign, prepubertal-type teratoma composed entirely of mature elements. Surgical intervention is commonly used for the management of benign testicular tumors in pediatric patients, including prepubertal teratomas. This approach demonstrates an excellent prognosis as it does not elevate the likelihood of recurrence. Prepubertal-type teratomas have rarely been reported in the infantile testis. They may present as a solid mass indistinguishable from the testicle, with no signs of inflammation.

摘要

睾丸肿瘤在儿童中较为罕见,仅占小儿实体瘤的一小部分,发病率为每10万名男性中有2例。畸胎瘤是婴儿中最常见的肿瘤,可表现为成熟型、未成熟型或恶性型。虽然成熟畸胎瘤通常见于腹部,但婴儿睾丸内青春期前型畸胎瘤并不常见。本研究描述了一例睾丸内成熟畸胎瘤的婴儿病例。一名6个月大的男婴出现右侧阴囊肿胀,其父母发现了这一情况。无类似疾病家族史,病史调查未发现任何显著异常。体格检查发现一个不可复性实性肿块,与右侧睾丸难以区分,无炎症迹象或全身症状。阴囊超声检查证实睾丸内有一个大囊肿。甲胎蛋白和β-人绒毛膜促性腺激素水平正常。进行了手术肿瘤剜除术,组织病理学检查显示为良性青春期前型畸胎瘤,完全由成熟成分组成。手术干预常用于小儿患者良性睾丸肿瘤的治疗,包括青春期前畸胎瘤。这种方法预后良好,因为它不会增加复发的可能性。青春期前型畸胎瘤在婴儿睾丸中很少见。它们可能表现为与睾丸难以区分的实性肿块,无炎症迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/11273244/485c390427bc/mi-04-05-00177-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/11273244/1c4d42e4c122/mi-04-05-00177-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/11273244/485c390427bc/mi-04-05-00177-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/11273244/1c4d42e4c122/mi-04-05-00177-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c01/11273244/485c390427bc/mi-04-05-00177-g01.jpg

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Ann Med Surg (Lond). 2023 Sep 7;85(11):5666-5669. doi: 10.1097/MS9.0000000000001274. eCollection 2023 Nov.
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Testis-Preserving Tumor Enucleation Is Applicable in Children with Immature Testicular Teratoma.保留睾丸的肿瘤剜除术适用于儿童未成熟睾丸畸胎瘤。
Urol Int. 2021;105(1-2):27-30. doi: 10.1159/000510526. Epub 2020 Nov 11.
3
Testicular teratoma demanded in-depth pathological exploration to rule out malignancy: A pediatric case report.
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IJU Case Rep. 2019 Mar 2;2(3):115-117. doi: 10.1002/iju5.12050. eCollection 2019 May.
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Mature and immature teratoma: A report from the second Italian pediatric study.成熟性和不成熟性畸胎瘤:来自意大利第二次儿科研究的报告。
Pediatr Blood Cancer. 2015 Jul;62(7):1202-8. doi: 10.1002/pbc.25423. Epub 2015 Jan 28.
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Antenatally detected mature teratoma in an undescended testis.产前检测到隐睾内的成熟畸胎瘤。
Eur J Pediatr Surg. 2011 May;21(3):209-10. doi: 10.1055/s-0031-1275678. Epub 2011 May 16.
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