Nezu Kunihisa, Endo Yuji, Katayama Hiromichi, Nozawa Yoshihiro, Kyan Atsushi
Department of Urology Shirakawa Kousei General Hospital Shirakawa Fukushima Japan.
Department of Orthopedic Surgery Shirakawa Kousei General Hospital Shirakawa Fukushima Japan.
IJU Case Rep. 2019 Jul 4;2(6):303-306. doi: 10.1002/iju5.12104. eCollection 2019 Nov.
Atypical femoral fractures are atraumatic or minimally traumatic fractures and rare side effects of bone resorption inhibitors. Bone resorption inhibitors are frequently used in the treatment of prostate cancer.
A 62-year-old man complained of difficulty in walking and left lower limb pain. Androgen deprivation and denosumab therapy for prostate cancer-induced bone metastasis was initiated 27 months ago. Even though the prostate-specific antigen level did not increase, imaging studies indicated the possibility of bone metastasis. The patient underwent bone biopsy; however, no malignancy was detected. Afterward, he had a fall, causing a complete fracture in his left femur.
Atypical femoral fractures occasionally mimic typical imaging findings and outcomes of bone metastasis. This case is important for recognizing such cases.