Shinohara Mayuka, Shin Toshitaka, Daa Tsutomu, Mimata Hiromitsu
Department of Urology Oita University Faculty of Medicine Yufu Oita Japan.
Department of Pathology Oita University Faculty of Medicine Yufu Oita Japan.
IJU Case Rep. 2020 Feb 20;3(2):76-78. doi: 10.1002/iju5.12151. eCollection 2020 Mar.
Primary pure choriocarcinoma of the bladder is extremely rare and should be distinguished from urothelial carcinoma. GATA-3 is a zinc finger transcription factor and a known sensitive immunostaining marker for urothelial carcinoma. However, its accuracy in the detection of urothelial carcinoma is moderate and it is also an important factor in trophoblast differentiation.
A 78-year-old man presented with asymptomatic gross hematuria for 6 months. Cystoscopy and clinical imaging revealed local bladder carcinoma. He underwent a radical cystectomy and histological diagnosis revealed pure choriocarcinoma (pT2aN0M0) with positive immunostaining, indicating GATA-3 was present. Systemic chemotherapy could not be applied due to his poor general condition, and he died 7 months after surgery.
We reported the first case of pure choriocarcinoma of the bladder, which showed positive immunostaining results indicating the presence of GATA-3.
原发性膀胱纯绒毛膜癌极为罕见，应与尿路上皮癌相鉴别。GATA-3是一种锌指转录因子，是已知的尿路上皮癌敏感免疫染色标志物。然而，其在尿路上皮癌检测中的准确性中等，并且它也是滋养层分化的一个重要因素。
一名78岁男性，出现无症状肉眼血尿6个月。膀胱镜检查和临床影像学检查发现局部膀胱癌。他接受了根治性膀胱切除术，组织学诊断为纯绒毛膜癌（pT2aN0M0），免疫染色呈阳性，表明存在GATA-3。由于他的全身状况较差，无法进行全身化疗，他在手术后7个月死亡。
我们报告了首例膀胱纯绒毛膜癌病例，其免疫染色结果呈阳性，表明存在GATA-3。
