Minamino Keizo, Adachi Yasushi, Okamura Akiharu, Kushida Taketoshi, Sugi Motohiko, Watanabe Masato, Muguruma Kouei, Sugao Hideki, Suzuki Yasuhiro, Iwasaki Masayoshi, Nakano Keiji, Koike Yasushi, Wang Jianfeng, Mukaide Hiromi, Zhang Yuming, Matsuda Tadashi, Matsumura Miyo, Ikehara Susumu
First Department of Pathology, Kansai Medical University, Moriguchi, Osaka, Japan.
Pathol Int. 2005 Apr;55(4):216-22. doi: 10.1111/j.1320-5463.2005.01814.x.
Choriocarcinomas usually develop in the uterus and ovaries in the female, being extremely rare in the extragenital organs in the male. Extragenital choriocarcinomas in the male usually develop in the mediastinum or retroperitoneum. The frequency of choriocarcinoma in the urinary bladder is extremely low. The purpose of the present paper was to report an autopsy case of choriocarcinoma in the urinary bladder in the male. An 81-year-old male patient with macrohematuria was first diagnosed with transitional cell carcinoma (TCC). At autopsy a hemorrhagic necrotic tumor, which was found in the urinary bladder with metastatic lesions in the lungs, was diagnosed as choriocarcinoma microscopically. There was no evidence for choriocarcinoma derived from any other organs than the urinary bladder, although there were metastatic lesions in both lungs and the direct invasion into the prostate. From these findings it is concluded that the tumor was a primary choriocarcinoma in the urinary bladder in a male patient. Choriocarcinoma of the urinary bladder is very rare, but the prognosis is extremely poor in comparison with TCC even in the urinary bladder. Therefore, it is essential to clearly discriminate between choriocarcinomas and TCC.
绒毛膜癌通常发生于女性的子宫和卵巢，在男性的生殖器外器官极为罕见。男性生殖器外绒毛膜癌通常发生于纵隔或腹膜后。膀胱癌中绒毛膜癌的发生率极低。本文旨在报告一例男性膀胱绒毛膜癌的尸检病例。一名81岁男性患者因肉眼血尿最初被诊断为移行细胞癌（TCC）。尸检时，在膀胱发现一个出血性坏死肿瘤，肺部有转移灶，显微镜下诊断为绒毛膜癌。尽管肺部有转移灶且肿瘤直接侵犯前列腺，但没有证据表明绒毛膜癌来源于膀胱以外的任何其他器官。根据这些发现得出结论，该肿瘤是一名男性患者膀胱原发性绒毛膜癌。膀胱绒毛膜癌非常罕见，但即使在膀胱中，与TCC相比预后也极差。因此，明确区分绒毛膜癌和TCC至关重要。
