p53 表达与犬脂肪肉瘤黏液样变亚型和更高的增殖活性相关。
p53 Expression in Canine Liposarcoma Correlates With Myxoid Variant and Higher Proliferative Activity.
机构信息
University di Bologna, Ozzano dell'Emilia, Italy.
University of Milano, Lodi, Italy.
出版信息
Vet Pathol. 2020 Sep;57(5):620-622. doi: 10.1177/0300985820941501. Epub 2020 Aug 3.
Canine liposarcoma is classified as well differentiated (WDL), dedifferentiated (DDL), myxoid (ML), and pleomorphic (PL). Overexpression of the protooncogene MDM2 has been reported in WDL and DDL, but little is known regarding the role of p53 in their tumorigenesis. The aim of this study was to assess p53 expression in canine liposarcoma and compare it with subtype, grade, mitotic count (MC), Ki67 labeling index (LI), and MDM2 expression. Forty-seven cases were included (13 WDL, 3 DDL, 7 ML, and 24 PL); 17 were MDM2-positive (13 WDL, 3DDL, and 1ML). Five were p53-positive (4 ML and 1 WDL) but DDL and PL were consistently negative. p53 expression correlated with higher Ki67-LI, higher MC, and myxoid histotype. No correlation was found with grade and MDM2 expression. Based on these results canine liposarcoma seems to embody a group of neoplasms whose subtypes, especially ML, may represent distinct diseases rather than morphological variants of the same entity.
犬脂肪肉瘤分为高分化型（WDL）、去分化型（DDL）、黏液样型（ML）和多形性型（PL）。已报道 WDL 和 DDL 中存在原癌基因 MDM2 的过表达，但关于其肿瘤发生中 p53 的作用知之甚少。本研究旨在评估犬脂肪肉瘤中 p53 的表达，并将其与亚型、分级、有丝分裂计数（MC）、Ki67 标记指数（LI）和 MDM2 表达进行比较。共纳入 47 例（13 例 WDL、3 例 DDL、7 例 ML 和 24 例 PL）；17 例 MDM2 阳性（13 例 WDL、3 例 DDL 和 1 例 ML）。5 例 p53 阳性（4 例 ML 和 1 例 WDL），但 DDL 和 PL 始终为阴性。p53 表达与更高的 Ki67-LI、更高的 MC 和黏液样组织学类型相关。与分级和 MDM2 表达无相关性。基于这些结果，犬脂肪肉瘤似乎体现了一组肿瘤，其亚型，尤其是 ML，可能代表不同的疾病，而不是同一实体的形态学变异。
Zotero 插件