美国大型三级医疗炎症性肠病中心队列中袋状相关疾病患者的疾病与治疗模式
Disease and Treatment Patterns Among Patients With Pouch-related Conditions in a Cohort of Large Tertiary Care Inflammatory Bowel Disease Centers in the United States.
作者信息
Barnes Edward L, Raffals Laura, Long Millie D, Syal Gaurav, Kayal Maia, Ananthakrishnan Ashwin, Cohen Benjamin, Pekow Joel, Deepak Parakkal, Colombel Jean-Frederic, Herfarth Hans H, Sandler Robert S
机构信息
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina, USA.
Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA.
出版信息
Crohns Colitis 360. 2020 Jul;2(3):otaa039. doi: 10.1093/crocol/otaa039. Epub 2020 Jul 24.
BACKGROUND
Gaps exist in our understanding of the clinical course of pouch-related disorders.
METHODS
We evaluated baseline disease activity and longitudinal treatment patterns among patients with inflammatory conditions of the pouch.
RESULTS
Among 468 patients with an ileal pouch-anal anastomosis (IPAA), 94 (20%) had acute pouchitis, 96 (21%) had chronic pouchitis, and 192 (41%) had Crohn disease of the pouch. Following an IPAA, 38% of patients were treated with a biologic and 11% underwent inflammatory bowel disease- or bowel-related surgery.
CONCLUSIONS
Treatment patterns after IPAA indicate that pouch-related disorders have a significant impact on individual patients and the healthcare system.
背景
我们对贮袋相关疾病临床病程的理解存在空白。
方法
我们评估了贮袋炎性疾病患者的基线疾病活动度和纵向治疗模式。
结果
在468例回肠贮袋肛管吻合术（IPAA）患者中，94例（20%）发生急性贮袋炎，96例（21%）发生慢性贮袋炎，192例（41%）发生贮袋克罗恩病。IPAA术后，38%的患者接受了生物制剂治疗，11%的患者接受了炎症性肠病或肠道相关手术。
结论
IPAA术后的治疗模式表明，贮袋相关疾病对个体患者和医疗保健系统有重大影响。
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