Department of Radiation Oncology, The First Affiliated Hospital of China Medical University, Liaoning, 110001, China.
Biomed Pharmacother. 2020 Oct;130:110567. doi: 10.1016/j.biopha.2020.110567. Epub 2020 Jul 31.
Cancer is one of the major threats to human health. It is of vital importance to reveal the mechanisms of tumorigenesis, identify effective biomarkers and develop novel treatments to improve patient outcome. EFNA1 (ephrinA1) is a member of the EFN family, and it has been studied extensively since its discovery in 1990. Increasing evidence indicates that EFNA1 plays a pivotal role in the pathogenesis of tumors. We provide a detailed overview of the expression and prognostic value of EFNA1 in different types of human malignancies. We briefly discuss the mechanisms of EFNA1 induction in hypoxic environments and its pro-angiogenic function in different cancer cells. We describe the effects of EFNA1 on tumor growth, invasiveness and metastasis. We summarize recent advances in EFNA1-associated cancer therapeutics with emphasis on the prospect of novel anti-tumor methods based on EFNA1.
癌症是人类健康的主要威胁之一。揭示肿瘤发生的机制、识别有效的生物标志物和开发新的治疗方法以改善患者预后至关重要。EFNA1（ephrinA1）是 EFN 家族的一员，自 1990 年发现以来，它已经得到了广泛的研究。越来越多的证据表明 EFNA1 在肿瘤的发病机制中起着关键作用。我们详细概述了 EFNA1 在不同类型人类恶性肿瘤中的表达和预后价值。我们简要讨论了 EFNA1 在低氧环境中的诱导机制及其在不同癌细胞中的促血管生成功能。我们描述了 EFNA1 对肿瘤生长、侵袭和转移的影响。我们总结了 EFNA1 相关癌症治疗的最新进展，重点介绍了基于 EFNA1 的新型抗肿瘤方法的前景。
