Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Brain Research Centre, National Yang-Ming University, Taipei, Taiwan.
Department of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Seizure. 2020 Oct;81:53-57. doi: 10.1016/j.seizure.2020.07.025. Epub 2020 Jul 28.
Depression is the most commonly seen psychiatric co-morbidity of epilepsy. Depression in patients with epilepsy (PWE) is underrecognized. The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) is a useful tool to screen for major depressive episodes (MDEs) in PWE. This study validated the Taiwanese version of the NDDI-E using data from adult PWE in our hospital.
PWE were recruited from the Taipei Veterans General Hospital from April 2017 to December 2019. The Chinese version of the NDDI-E for the Taiwanese population and the Beck Depression Inventory-II (BDI-II) were completed as part of the self-rated psychiatric assessments. The mood disorder module of the Mini International Neuropsychiatric Interview (MINI) was completed as part of the psychiatric assessment before the self-rated assessment. Internal consistency, external validation, and receiver operator characteristic (ROC) curve analysis were used to assess the utility of the Taiwanese version of the NDDI-E.
We recruited 109 patients during the 33-month study period. The mean age was 33.1 ± 8.94 years old. The mean NDDI-E score was 12.32 ± 4.96. The mean BDI-II score was 13.26 ± 12.77. All NDDI-E items were significantly positively associated with the corrected overall NDDI-E score (Cronbach's alpha = 0.902, r = 0.825, p < 0.0001). The cut-off point for the NDDI-E determined with receiver operating characteristic (ROC) curve analysis is 15 (sensitivity = 85.0%, specificity = 87.64%).
The Chinese version of the NDDI-E adapted for the Taiwanese population is a reliable and valid self-reported questionnaire for detecting MDE in Taiwanese PWE.
抑郁症是癫痫最常见的合并精神疾病。癫痫患者（PWE）的抑郁症未得到充分认识。神经障碍抑郁量表-癫痫版（NDDI-E）是一种用于筛查 PWE 中重度抑郁发作（MDE）的有用工具。本研究使用我院成人 PWE 的数据验证了 NDDI-E 的台湾中文版。
从 2017 年 4 月至 2019 年 12 月，从台北荣民总医院招募 PWE。作为自评性精神评估的一部分，完成了针对台湾人群的 NDDI-E 中文版本和贝克抑郁量表-第二版（BDI-II）。在自评性评估之前，作为精神评估的一部分，完成了迷你国际神经精神访谈（MINI）的心境障碍模块。使用内部一致性、外部验证和接收者操作特征（ROC）曲线分析来评估台湾版 NDDI-E 的效用。
在 33 个月的研究期间，我们招募了 109 名患者。平均年龄为 33.1±8.94 岁。NDDI-E 评分的平均值为 12.32±4.96。BDI-II 评分的平均值为 13.26±12.77。所有 NDDI-E 项目均与校正后的总体 NDDI-E 评分显著正相关（Cronbach's alpha=0.902，r=0.825，p<0.0001）。通过 ROC 曲线分析确定的 NDDI-E 切点为 15（灵敏度=85.0%，特异性=87.64%）。
针对台湾人群改编的 NDDI-E 中文版本是一种可靠有效的自评问卷，可用于检测台湾 PWE 中的 MDE。
