Republican Specialized Scientific and Practical Medical Center of Tuberculosis and Pulmonology, 100086, Tashkent, Uzbekistan.
Team of Environmental Biotechnology, AGH University of Science and Technology, 300-059, Krakow, Poland; Tashkent Institute of Irrigation and Agricultural Mechanization Engineers, 100000, Tashkent, Uzbekistan; Shanghai Jiao Tong University, 200240, Shanghai, China.
Tuberculosis (Edinb). 2020 Sep;124:101963. doi: 10.1016/j.tube.2020.101963. Epub 2020 Jul 21.
The spread of tuberculosis is directly related to the processes of globalization and migration. Tuberculosis has also been the main cause of fatality associated with antimicrobial resistance and also the main cause of death in people who have HIV infection. Additionally, tuberculosis smites the lungs in 80% of patients, and in the remaining 20% of patients the tuberculosis may smites other organs, such as the vision/eye. Ocular tuberculosis is a specific infectious disease of bacterial etiology with a chronic and persistent course, the prognosis of which is extremely doubtful. Even effective chemotherapy can be accompanied by a decrease in visual acuity, and clinical recovery is not always persistent. Ocular tuberculosis often leads to permanent disability and, as a result, the quality of life of patients decreases. A statistical reporting of this disease does not always reflect the true picture, since ocular tuberculosis sometimes develops against the background of an existing specific lesion in the lung tissue. Currently, ocular tuberculosis remains substantially a conjectural clinical diagnosis. This review paper presents an analytical review of the literature on the epidemiology, clinical features, and diagnosis methods of ocular tuberculosis. The results of recent studies that focused on the modern clinical manifestations of this pathology, its diagnosis, and complex therapy are systematized. The development of new rational regimens and pathogenetic treatment methods are also highlighted in this review.
结核病的传播与全球化和移民进程直接相关。结核病也是与抗微生物药物耐药性相关的主要致死原因，也是艾滋病毒感染者的主要死因。此外，80%的患者肺部受到结核病的侵袭，而在其余 20%的患者中，结核病可能侵袭其他器官，如视力/眼睛。眼部结核病是一种具有慢性和持续性病程的特定细菌性病因传染病，其预后极为不确定。即使进行有效的化疗，视力也可能下降，临床恢复也不总是持久的。眼部结核病常导致永久性残疾，因此患者的生活质量下降。这种疾病的统计报告并不总是反映真实情况，因为眼部结核病有时会在肺部组织中现有的特定病变的背景下发展。目前，眼部结核病仍然主要是一种推测性的临床诊断。本文对眼部结核病的流行病学、临床特征和诊断方法进行了文献分析综述。对集中于该病理学的现代临床表现、诊断和综合治疗的最新研究结果进行了系统化。本文还强调了新的合理治疗方案和发病机制治疗方法的发展。
