IEEE Trans Biomed Eng. 2021 Jan;68(1):276-288. doi: 10.1109/TBME.2020.2999539. Epub 2020 Dec 21.
Skin temperature has long been used as a natural indicator of vascular diseases in the extremities. Considerable correlation between oscillations in skin surface temperature and oscillations of skin blood flow has previously been demonstrated. We hypothesised that the impairment of blood flow in stenotic (subcutaneous) peripheral arteries would influence cutaneous temperature such that, by measuring gradients in the temperature distribution over skin surfaces, one may be able to diagnose or quantify the progression of vascular conditions in whose pathogenesis a reduction in subcutaneous blood perfusion plays a critical role (e.g. peripheral artery disease). As proof of principle, this study investigates the local changes in the skin temperature of healthy humans (15 male, [Formula: see text] years old, BMI [Formula: see text] kg/m ) undergoing two physical challenges designed to vary their haemodynamic status. Skin temperature was measured in four central regions (forehead, neck, chest, and left shoulder) and four peripheral regions (left upper arm, forearm, wrist, and hand) using an infrared thermal camera. We compare inter-region patterns. Median temperature over the peripheral regions decreased from baseline after both challenges (maximum decrease: [Formula: see text] °C at 60 s after exercise; [Formula: see text] and [Formula: see text] °C at 180 s of cold-water immersion; [Formula: see text]). Median temperature over the central regions showed no significant changes. Our results show that the non-contact measurement of perfusion-related changes in peripheral temperature from infrared video data is feasible. Further research will be directed towards the thermographic study of patients with symptomatic peripheral vascular disease.
皮肤温度长期以来一直被用作四肢血管疾病的自然指标。先前已经证明,皮肤表面温度的波动与皮肤血流的波动之间存在相当大的相关性。我们假设狭窄(皮下)外周动脉的血流受损会影响皮肤温度,通过测量皮肤表面温度分布的梯度,可以诊断或量化血管疾病的进展,在这些疾病的发病机制中,皮下血流灌注减少起着关键作用(例如,外周动脉疾病)。作为原理证明,本研究调查了健康人类(15 名男性,[公式:见文本]岁,BMI [公式:见文本] kg/m )的皮肤温度的局部变化,这些人经历了两个旨在改变其血液动力学状态的身体挑战。使用红外热像仪测量了四个中央区域(前额、颈部、胸部和左肩)和四个外周区域(左上臂、前臂、手腕和手)的皮肤温度。我们比较了区域间的模式。在两个挑战之后,外周区域的中位数温度从基线开始下降(最大下降:运动后 60 秒时[公式:见文本]摄氏度;冷水浸泡 180 秒时为[公式:见文本]和[公式:见文本]摄氏度)。中央区域的中位数温度没有明显变化。我们的结果表明,从红外视频数据中非接触式测量外周温度的灌注相关变化是可行的。进一步的研究将针对有症状的外周血管疾病患者的热成像研究。