IEEE Trans Biomed Eng. 2021 Jul;68(7):2049-2057. doi: 10.1109/TBME.2020.3013519. Epub 2021 Jun 17.
Point-of-care devices can analyze or characterize a sample in a short time. New technologies in medical science seek integrations of different measurement techniques for a complete analysis. This study describes the fabrication method, tests, and results of microtechnology as an approach for an integrated rheometer. The portable device measured the average flow velocity to calculate its viscosity. The whole system encompasses a microdevice integrated to a data acquisition system powered by USB and controlled by full custom software. As a result, we obtained an easy-to-handle and fabricate hand-held microrheometer. The device was tested using Newtonian fluids such as Mili-Q water, an aqueous solution of Ethylene-glycol at 40% and 25% and Non-Newtonian blood samples. The whole device can provide the non-linear viscosity of a 0.08 ml blood sample in less than 30 seconds, in a wide range of shear rate with an accuracy of 93%. More importantly, due to its detection method and simplicity, it can be enclosed within almost any fluidic microsystem, including biomedical applications.
即时检测设备可以在短时间内分析或表征样本。医学科学中的新技术寻求不同测量技术的整合，以进行全面分析。本研究描述了微技术的制造方法、测试和结果，作为集成流变仪的一种方法。该便携式设备测量平均流速以计算其粘度。整个系统包括一个集成到数据采集系统的微设备，该系统由 USB 供电，并由全定制软件控制。结果，我们获得了一种易于操作和制造的手持式微流变仪。该设备使用牛顿流体（如 Mili-Q 水、40%和 25%的乙二醇水溶液）和非牛顿血液样本进行了测试。整个设备可以在不到 30 秒的时间内提供 0.08 毫升血液样本的非线性粘度，在宽剪切率范围内具有 93%的精度。更重要的是，由于其检测方法简单，可以将其封装在几乎任何流体微系统中，包括生物医学应用。
