栽培假糙苏叶中的二萜类化合物。

Diterpenoids from Leaves of Cultivated Plectranthus ornatus.

机构信息

Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, Fortaleza-CE, Brazil.

Núcleo de Pesquisa e Desenvolvimento de Medicamentos, Universidade Federal do Ceará, Fortaleza-CE, Brazil.

出版信息

Planta Med. 2021 Feb;87(1-02):124-135. doi: 10.1055/a-1209-3252. Epub 2020 Aug 3.

DOI:10.1055/a-1209-3252

PMID:32746472

Abstract

Two new diterpenoid derivatives 7,12,17-triacetoxy-619-dihydroxy-13,16-spirocicloabiet-8-ene-11,14-dione ( 1: ) and 6-acetoxy-3,7,12-trihydroxy-13,16-spirocicloabiet-8-ene-11,14-dione ( 2: ) along with 11 ( 3: - 13: ) miscellaneous compounds were isolated from the leaves of Codd. Their structures were elucidated by spectroscopic analysis and gauge independent atomic orbitals C NMR calculations. The isolated compounds were screened for their effects on intestinal motility using guinea-pig ileum and duodenum and by their cytotoxicity against 4 human cancer cell lines (HCT-116, SF-295, PC-3, and HL-60). Compounds 6: and 9: were moderately cytotoxic against HL-60, whereas 6: and 13: were more active on SF-295 and HCT-116.

摘要

从 Codd 的叶子中分离得到了两个新的二萜类衍生物 7,12,17-三乙酰氧基-6β,19-二羟基-13,16-螺环环阿尔廷-8-烯-11,14-二酮（1：）和 6-乙酰氧基-3,7,12-三羟基-13,16-螺环环阿尔廷-8-烯-11,14-二酮（2：）以及 11（3：-13：）杂化合物。通过光谱分析和规范无关原子轨道 C NMR 计算确定了它们的结构。对分离得到的化合物进行了肠道动力活性筛选，采用豚鼠回肠和十二指肠进行测试，同时还对其对 4 个人类癌细胞系（HCT-116、SF-295、PC-3 和 HL-60）的细胞毒性进行了测试。化合物 6：和 9：对 HL-60 具有中等细胞毒性，而 6：和 13：对 SF-295 和 HCT-116 更具活性。