Department of Biological Chemistry, Regional University of Cariri-URCA, Crato 63105-000, CE, Brazil.
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Molecules. 2023 Jul 26;28(15):5653. doi: 10.3390/molecules28155653.
The use of medicinal plants to treat inflammatory conditions and painful processes has attracted the attention of scientists and health professionals due to the evidence that natural products can promote significant therapeutic benefits associated with fewer adverse effects compared to conventional anti-inflammatory drugs. The genus is composed of various plants with pharmacological potential, which are used to treat various diseases in traditional communities worldwide. The present study systematically reviewed species with anti-inflammatory and analgesic potential. To this end, a systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. The search was conducted on the following databases: PubMed, ScienceDirect, SciVerse Scopus, and Web of Science. Different combinations of search terms were used to ensure more excellent article coverage. After the selection, a total of 45 articles were included in this review. This study identified twelve species indicated for the treatment of different inflammatory conditions, such as wounds, fever, bronchitis, abscess, asthma, hepatitis, labyrinthitis, tonsillitis, and uterine inflammation. The indications for pain conditions included headache, sore throat, heartburn, menstrual cramp, colic, toothache, stomachache, migraine, chest pain, abdominal pain, local pain, labor pain, and recurring pain. Among the listed species, ten plants were found to be used according to traditional knowledge, although only four of them have been experimentally studied. When assessing the methodological quality of preclinical in vivo assays, most items presented a risk of bias. The SR results revealed the existence of different species used to treat inflammation and pain. The results of this systematic review indicate that species have the potential to be used in the treatment of diseases with an inflammatory component, as well as in the management of pain. However, given the risk of biases, the experimental analysis of these species through preclinical testing is crucial for their safe and effective use.
药用植物治疗炎症和疼痛过程的应用引起了科学家和健康专业人员的关注，因为有证据表明，与传统抗炎药物相比，天然产品可以带来显著的治疗益处，同时副作用较少。属由具有药理潜力的各种植物组成，在世界各地的传统社区中用于治疗各种疾病。本研究系统地综述了具有抗炎和镇痛潜力的 种。为此，按照系统评价和荟萃分析的首选报告项目（PRISMA）协议进行了系统评价。在以下数据库中进行了搜索：PubMed、ScienceDirect、SciVerse Scopus 和 Web of Science。使用不同的搜索词组合以确保更好地涵盖文章。选择后，共有 45 篇文章被纳入本综述。本研究确定了 12 种用于治疗不同炎症的 种，如伤口、发热、支气管炎、脓肿、哮喘、肝炎、迷路炎、扁桃体炎、子宫炎。用于疼痛病症的适应症包括头痛、喉咙痛、胃灼热、痛经、绞痛、牙痛、胃痛、偏头痛、胸痛、腹痛、局部疼痛、分娩疼痛和反复疼痛。在所列出的物种中，有 10 种植物根据传统知识使用，尽管其中只有 4 种经过了实验研究。在评估体内临床前试验的方法学质量时，大多数项目都存在偏倚风险。SR 结果显示存在不同的 种用于治疗炎症和疼痛。本系统评价的结果表明， 种具有治疗具有炎症成分的疾病以及管理疼痛的潜力。然而，由于存在偏倚风险，通过临床前试验对这些物种进行实验分析对于它们的安全和有效使用至关重要。
