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Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes.

作者信息

Heurteau Alexandre, Perrois Charlène, Depierre David, Fosseprez Olivier, Humbert Jonathan, Schaak Stéphane, Cuvier Olivier

机构信息

Chromatin Dynamics and Cell Proliferation, Center of Integrative Biology (CBI), Laboratoire de Biologie Moléculaire Eucaryote (LBME), CNRS, Université Fédérale Paul Sabatier de Toulouse (UPS), F-31000, Toulouse, France.

St. Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Centre Hospitalier Universitaire de Québec City, Quebec, QC, G1R 3S3, Canada.

出版信息

Genome Biol. 2020 Aug 3;21(1):193. doi: 10.1186/s13059-020-02106-z.

DOI:10.1186/s13059-020-02106-z
PMID:32746892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7397589/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/1f299ef1841c/13059_2020_2106_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/c5c4b2d1e79b/13059_2020_2106_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/4b7b58dc5ccc/13059_2020_2106_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/51112924fde0/13059_2020_2106_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/e040e225c7c0/13059_2020_2106_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/9e46ae664940/13059_2020_2106_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/938295103342/13059_2020_2106_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/1f299ef1841c/13059_2020_2106_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/c5c4b2d1e79b/13059_2020_2106_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/4b7b58dc5ccc/13059_2020_2106_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/51112924fde0/13059_2020_2106_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/e040e225c7c0/13059_2020_2106_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/9e46ae664940/13059_2020_2106_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/938295103342/13059_2020_2106_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a980/7397589/1f299ef1841c/13059_2020_2106_Fig7_HTML.jpg

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Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27.
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The BEN Domain Protein Insensitive Binds to the Chromatin Boundary To Establish Proper Segmental Identity in .
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iScience. 2023 Dec 3;27(1):108624. doi: 10.1016/j.isci.2023.108624. eCollection 2024 Jan 19.
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Chromatin in 3D distinguishes dMes-4/NSD and Hypb/dSet2 in protecting genes from H3K27me3 silencing.三维染色质区分 dMes-4/NSD 和 Hypb/dSet2，以保护基因免受 H3K27me3 沉默。
Life Sci Alliance. 2023 Sep 8;6(11). doi: 10.26508/lsa.202302038. Print 2023 Nov.
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