Dominici Laura S, Rosenberg Shoshana M
Brigham and Women's Hospital, Boston, MA.
Dana-Farber Cancer Institute, Boston, MA.
Curr Breast Cancer Rep. 2020 Jun;12(2):90-97. doi: 10.1007/s12609-020-00363-2. Epub 2020 Apr 4.
Patient reported outcomes (PROs) are an optimal method for assessing quality of life (QOL), including physical and psychosocial health. This review summarizes PROs frequently assessed in the setting of a DCIS diagnosis.
Health-related QOL has generally been found to be modestly affected in women with DCIS and similar to women with invasive breast cancer. Several studies reported a substantial negative impact on sexual health and body image, including some differences based on surgery type. Some patients experience pain after treatment, although many physical symptoms resolve. The prevalence of anxiety and depression varied based on assessment timing, with symptoms improving over time. Women with DCIS often overestimate the risks associated both with DCIS and invasive cancer.
PROs provide critical information regarding the experiences of women following a DCIS diagnosis. Continued inclusion of PROs in clinical trials is warranted, further informing treatment decisions and adequately preparing patients for what to expect following treatment.
患者报告结局（PROs）是评估生活质量（QOL）的最佳方法，包括身体和心理社会健康。本综述总结了在导管原位癌（DCIS）诊断背景下经常评估的PROs。
一般发现，DCIS女性的健康相关生活质量受到适度影响，与浸润性乳腺癌女性相似。几项研究报告了对性健康和身体形象的重大负面影响，包括基于手术类型的一些差异。一些患者在治疗后会经历疼痛，尽管许多身体症状会消失。焦虑和抑郁的患病率因评估时间而异，症状会随着时间改善。DCIS女性通常高估与DCIS和浸润性癌症相关的风险。
PROs提供了有关DCIS诊断后女性经历的关键信息。有必要在临床试验中持续纳入PROs，进一步为治疗决策提供信息，并让患者充分了解治疗后可能出现的情况。
