Taneja Gargi, Hazarika Neirita, Bhatia Riti
Department of Dermatology and Venereology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.
Dermatol Ther. 2020 Nov;33(6):e14122. doi: 10.1111/dth.14122. Epub 2020 Aug 24.
Viral warts are well-defined, hyperkeratotic mucocutaneous lesions caused by human papilloma virus infection, that can occur anywhere on the body. Various medical and surgical modalities are required for treatment of warts as spontaneous regression is rarely seen. Despite the availability of multiple treatment options, warts are often recurrent and resistant to treatment. The effectiveness of autoinoculation in the treatment of multiple or recurrent verruca was evaluated. Consecutive cases with at least five warts or recurrent warts were included. A treatment-free washout period of 1 month was ensured. Patients with verruca vulgaris (n = 13), palmoplantar (n = 4), periungual (n = 5) were included in the study. The warty tissue was excised, minced and homogenous tissue implanted in a small dermal pocket in the left forearm. Patients were evaluated every 4 weeks. The procedure was repeated at 4th and 8th week. Response was assessed at each visit and at 12th week. Fifteen cases were recruited. Majority of the patients were diagnosed with verruca vulgaris (87%, n = 13) followed by periungual warts (33%, n = 5) and palmoplantar warts (27%, n = 4). Recurrent warts were present in 73% (n = 11) patients. Average improvement at the end of 12 weeks was seen in 65% cases. Ten (67%) patients showed complete resolution of warts. In two patients, warts increased in number while on treatment. Local site infection was seen in two patients. The study is limited by its small sample size. Autoinoculation is an effective modality of treatment for multiple and recurrent warts. Furthermore, it is an effective treatment modality for periungual and plantar warts, which are usually resistant to other modalities.
病毒性疣是由人乳头瘤病毒感染引起的界限清晰、角化过度的黏膜皮肤损害，可发生于身体的任何部位。由于很少见到自发消退，因此治疗疣需要多种医学和外科方法。尽管有多种治疗选择，但疣往往会复发且对治疗有抵抗性。对自体接种疗法治疗多发或复发性疣的有效性进行了评估。纳入了至少有5个疣或复发性疣的连续病例。确保有1个月的无治疗洗脱期。研究纳入了寻常疣患者（n = 13）、掌跖疣患者（n = 4）、甲周疣患者（n = 5）。将疣状组织切除、切碎，然后将均匀的组织植入左前臂的一个小真皮袋中。每4周对患者进行评估。在第4周和第8周重复该操作。在每次就诊时以及第12周评估反应情况。共招募了15例患者。大多数患者被诊断为寻常疣（87%，n = 13），其次是甲周疣（33%，n = 5）和掌跖疣（27%，n = 4）。73%（n = 11）的患者有复发性疣。12周结束时，65%的病例有平均改善。10例（67%）患者的疣完全消退。2例患者在治疗期间疣的数量增加。2例患者出现局部感染。该研究受样本量小的限制。自体接种是治疗多发和复发性疣的一种有效方法。此外，它是治疗甲周疣和跖疣的一种有效治疗方法，而这些疣通常对其他方法有抵抗性。
