National Engineering Laboratory for Rice and By-Product Deep Processing, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, China.
Central Laboratory for Medical Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033819892261. doi: 10.1177/1533033819892261.
As one of the common cancers that threaten human life, the recurrence and metastasis of colorectal cancer seriously affect the prognosis of patients. Although new drugs and comprehensive treatments have been adopted, the current treatment effect on this tumor, especially in advanced colorectal cancer, is still not satisfactory. More and more evidence shows that tumors are likely to be a stem cell disease. In recent years, the rise of cancer stem cell theory has provided a new way for cancer treatment. Studies have found that a small number of special cells in colorectal cancer tissues that induce tumorigenesis, proliferation, and promote tumor migration and metastasis, namely, colorectal cancer stem cells. Colorectal cancer stem cells are defined with a group of cell-surface markers, such as CD44, CD133, CD24, epithelial cell adhesion factor molecule, LGR5, and acetaldehyde dehydrogenase. They are highly tumorigenic, aggressive, and chemoresistant and thus are critical in the metastasis and recurrence of colorectal cancer. Therefore, targeting colorectal cancer stem cells may become an important research direction for the future cure of colorectal cancer.
作为威胁人类生命的常见癌症之一，结直肠癌的复发和转移严重影响了患者的预后。尽管采用了新的药物和综合治疗方法，但目前对这种肿瘤的治疗效果，特别是在晚期结直肠癌中，仍然不尽如人意。越来越多的证据表明，肿瘤可能是一种干细胞疾病。近年来，癌症干细胞理论的兴起为癌症治疗提供了新的途径。研究发现，结直肠组织中诱导肿瘤发生、增殖，并促进肿瘤迁移和转移的少数特殊细胞，即结直肠癌症干细胞。结直肠癌症干细胞被定义为具有一组细胞表面标志物的细胞群，例如 CD44、CD133、CD24、上皮细胞黏附因子分子、LGR5 和乙醛脱氢酶。它们具有高度的致瘤性、侵袭性和化疗耐药性，因此在结直肠癌的转移和复发中至关重要。因此，针对结直肠癌症干细胞可能成为未来治疗结直肠癌的一个重要研究方向。
