Cancer Institute, Department of Oncology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Immun Inflamm Dis. 2020 Dec;8(4):782-792. doi: 10.1002/iid3.335. Epub 2020 Aug 4.
Protein neddylation, one of the most important posttranslational modifications that tagging neuronal precursor cell-expressed developmentally downregulated protein 8 onto substrate proteins, plays fundamental roles in the process of many cellular functions. A number of studies have demonstrated the critical roles of neddylation modification in multiple pathophysiological processes, but its regulatory role in the immune system has only been finitely unveiled.
In this review, the latest advances in the field of neddylation modification in regulating the immune responses are succinctly discussed.
Neddylation modification acts as a crucial modulator of innate immune cells (neutrophils, macrophages, and dendritic cells) and lymphocytes. Dysregulation of neddylation alters characteristics and functions of those cells due to abnormal degradation of key signaling molecules involved in immunoregulation. Furthermore, the ectopic immune responses caused by the abnormal neddylation play pivotal roles in a variety of immune-related diseases, such as infection, inflammation, and cancer.
The pivotal roles of neddylation pathway in immunoregulation are attracted more and more attention, which may provide new insights into the pathogenesis of a variety of immune-related diseases and help to indicate new therapeutic targets and potential treatment strategies.
蛋白的类泛素化修饰是一种将神经元前体细胞表达的发育下调蛋白 8 标记到底物蛋白上的重要翻译后修饰方式，在许多细胞功能的过程中发挥着基本作用。许多研究已经证明了类泛素化修饰在多种病理生理过程中的关键作用，但它在免疫系统中的调节作用还只是初步揭示。
在这篇综述中，简要讨论了类泛素化修饰在调节免疫反应方面的最新进展。
类泛素化修饰作为先天免疫细胞（中性粒细胞、巨噬细胞和树突状细胞）和淋巴细胞的重要调节剂。由于参与免疫调节的关键信号分子的异常降解，类泛素化的失调改变了这些细胞的特征和功能。此外，异常的类泛素化引起的异位免疫反应在多种免疫相关疾病中起着关键作用，如感染、炎症和癌症。
类泛素化途径在免疫调节中的关键作用越来越受到关注，这可能为多种免疫相关疾病的发病机制提供新的见解，并有助于指出新的治疗靶点和潜在的治疗策略。
