Hansenol Int. 1988 Dec;13(2):47-56.
A 75 years old white male, for 3 years on treatment for virchowian hanseniasis, was admitted with active HD lesions, infiltration on the base of right lung, leg ulcer and malaise. After two days he developed purpura and hemorrhagic blisters in the limbs. The biopsy of these lesions revealed Lucio phenomenon. The patient worsened with mental confusion, psychomotor agitation and anisocoric pupils. In the 18th day of internation the patient died. Necropsy revealed virchowian infiltration plenty of bacilli in the skin and viscera as well as tuberculoid granuloma with acid-fast bacilli in the liver, spleen and bone marrow. These findings lead us to review the patient's classification from virchowian to borderline. In the lungs, leptomeninge, renal papile, prostate and thyroid it was found loose tuberculoid granuloma with a great amount of fungi surrounded by a gelly halo resembling Criptococcus neoformans. These findings and the onset of Lucio phenomenon are discussed in a patient that has been treated for 3 years and still having several virchowian lesions and a great amount of acid-fast bacilli.
一名75岁的白人男性,接受维氏汉森病治疗3年,因活跃的麻风病损、右肺底部浸润、腿部溃疡和不适入院。两天后,他四肢出现紫癜和出血性水疱。这些病损的活检显示为卢西奥现象。患者病情恶化,出现精神错乱、精神运动性激越和瞳孔不等大。住院第18天,患者死亡。尸检发现维氏浸润,皮肤和内脏有大量杆菌,肝脏、脾脏和骨髓有含抗酸杆菌的结核样肉芽肿。这些发现使我们将患者的分类从维氏型重新评估为边缘型。在肺、软脑膜、肾乳头、前列腺和甲状腺中,发现了松散的结核样肉芽肿,有大量真菌,周围有类似新型隐球菌的胶状晕圈。本文讨论了一名接受治疗3年仍有多处维氏病损和大量抗酸杆菌的患者的这些发现及卢西奥现象的发病情况。