Microorganisms. 2020 Jul 31;8(8):1164. doi: 10.3390/microorganisms8081164.
the International Cohort Consortium of Infectious Disease (RESPOND) is a collaboration dedicated to research on HIV and other infectious diseases.
RESPOND is a flexible organization, with several independent substudies operating under one shared governance. HIV-related variables, including full antiretroviral therapy (ART) history, are collected annually for all participants and merged with substudy specific data into a shared data pool. Incident clinical events are reported using standardized forms. Prospective follow-up started 1/10/17 (enrolment) with retrospective data collected back to 01/01/12.
Overall, 17 cohorts from Europe and Australia provided data on 26,258 people living with HIV (PLWH). The majority (43.3%) of the population were white, with men-sex-with-men accounting for 43.3% of the risk for HIV acquisition. The median age was 48 years (IQR 40-56) and 5.2% and 25.5% were known to be co-infected with hepatitis B or C. While 5.3% were ART-naïve, the median duration on ART was 10.1 years (4.8-17.6), with 89.5% having a VL <200 copies/mL and the median CD4 count being 621 cells/µL (438-830). Malignancies ( = 361) and cardiovascular disease ( = 168) were the predominant reported clinical events.
RESPOND's large, diverse study population and standardized clinical endpoints puts the consortium in a unique position to respond to the diverse modern challenges for PLWH.
国际传染病队列联盟（RESPOND）是一个致力于研究艾滋病毒和其他传染病的合作组织。
RESPOND是一个灵活的组织，有几个独立的子研究在一个共享治理下运作。每年为所有参与者收集与艾滋病毒相关的变量，包括完整的抗逆转录病毒治疗（ART）史，并与子研究特定数据合并到一个共享数据库中。使用标准化表格报告新发临床事件。前瞻性随访于2017年10月1日开始（入组），回顾性数据收集至2012年1月1日。
总体而言，来自欧洲和澳大利亚的17个队列提供了26258名艾滋病毒感染者（PLWH）的数据。大多数（43.3%）人群为白人，男男性行为者占艾滋病毒感染风险的43.3%。中位年龄为48岁（四分位间距40 - 56岁），已知合并感染乙型或丙型肝炎的比例分别为5.2%和25.5%。虽然5.3%的人未接受过抗逆转录病毒治疗，但抗逆转录病毒治疗的中位持续时间为10.1年（4.8 - 17.6年），89.5%的人的病毒载量<200拷贝/毫升，中位CD4细胞计数为621个/微升（438 - 830个/微升）。恶性肿瘤（n = 361）和心血管疾病（n = 168）是报告的主要临床事件。
RESPOND庞大、多样的研究人群和标准化的临床终点使该联盟处于应对PLWH面临的各种现代挑战的独特地位。
