Nicholson Matthew, Chan Noel, Bhagirath Vinai, Ginsberg Jeffrey
Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON L8N 3Z5, Canada.
J Clin Med. 2020 Aug 1;9(8):2467. doi: 10.3390/jcm9082467.
Venous thromboembolism (VTE) is the third most common cause of vascular mortality worldwide and comprises deep-vein thrombosis (DVT) and pulmonary embolism (PE). In this review, we discuss how an understanding of VTE epidemiology and the results of thromboprophylaxis trials have shaped the current approach to VTE prevention. We will discuss modern thromboprophylaxis as it pertains to genetic risk factors, exogenous hormonal therapies, pregnancy, surgery, medical hospitalization, cancer, and what is known thus far about VTE in COVID-19 infection.
静脉血栓栓塞症(VTE)是全球范围内血管性死亡的第三大常见原因,包括深静脉血栓形成(DVT)和肺栓塞(PE)。在本综述中,我们讨论了对VTE流行病学的理解以及血栓预防试验的结果如何塑造了当前VTE预防的方法。我们将讨论与遗传风险因素、外源性激素疗法、妊娠、手术、住院治疗、癌症相关的现代血栓预防措施,以及迄今为止已知的COVID-19感染中的VTE情况。