Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, 250012, Jinan, Shandong, China.
Mini Rev Med Chem. 2021;21(11):1367-1379. doi: 10.2174/1389557520666200804124924.
Benzimidazole is an aromatic bicyclic heterocycle that is regarded as a valuable privileged scaffold in medicinal chemistry. Many marketed drugs and natural products containing benzimidazole scaffolds exert great influence in fighting various diseases, such as hypertension, peptic ulcers, parasitic infections, and cancer. In this review, we introduce the pharmacological applications of some marketed drugs and lead compounds with a focus on anticancer agents, reporting the corresponding data to show the biological activities at their targets. The publications in this review encompass those from 2014 to 2019.
苯并咪唑是一种芳香的双环杂环化合物，被认为是药物化学中一种有价值的优势骨架。许多含有苯并咪唑骨架的上市药物和天然产物在对抗各种疾病方面发挥了巨大的作用，如高血压、消化性溃疡、寄生虫感染和癌症。在这篇综述中，我们介绍了一些上市药物和先导化合物的药理学应用，重点是抗癌药物，报告了相应的数据以显示其在靶点上的生物活性。本综述中的出版物涵盖了 2014 年至 2019 年的文献。
