Shimatani Akiyoshi, Hoshi Manabu, Oebisu Naoto, Iwai Tadashi, Takada Naoki, Nakamura Hiroaki
Department of Orthopedic Surgery, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan.
Mol Clin Oncol. 2020 Sep;13(3):17. doi: 10.3892/mco.2020.2088. Epub 2020 Jul 9.
In the aging society in Japan, the occurrence of multiple primary cancers has recently increased due to an increase in life expectancy and increased development in cancer diagnostic technology and improvement in treatment outcomes. However, few reports have focused on multiple primary cancers in patients with bone and soft tissue tumors. The present study aimed to analyze the clinical characteristics of patients with multiple malignancies of the bone and soft tissue. Between April 2008 and April 2017, among 973 patients treated at the Department of Orthopedic Surgery, Osaka City University Hospital, those with multiple primary cancers involving bone and soft tissue were identified. The number of cases with multiple cancers in the present study was 30/973 (3.08%), including 21 males and 9 females. The median age at diagnosis of patients with bone and soft tissue sarcoma was 73.5 years (range, 7-83 years). There were 22 patients with double cancers, and 5, 2 and 1 patients with triple, quadruple and quintuple cancers, respectively. Colorectal cancer was the most common primary cancer (n=9). In total, 28.6% of patients had simultaneous cancer, while 71.4% of patients had heterochronous cancer. The overall 5-year survival for all patients was 75.6%. The prognosis of patients with double cancer of bone and soft tissue sarcoma was not necessarily poor. However, it is necessary to pay attention to the possibility of secondary malignancy. Therefore, it is essential to be careful and well organized when selecting treatment modalities and to adopt a logistical approach for the care of patients with ongoing multiple malignancies.
在日本的老龄化社会中，由于预期寿命的增加、癌症诊断技术的发展以及治疗效果的改善，近年来多原发性癌症的发生率有所上升。然而，很少有报告关注骨与软组织肿瘤患者中的多原发性癌症。本研究旨在分析骨与软组织多原发性恶性肿瘤患者的临床特征。在2008年4月至2017年4月期间，在大阪市立大学医院骨科接受治疗的973例患者中，确定了患有涉及骨与软组织的多原发性癌症的患者。本研究中多原发性癌症的病例数为30/973（3.08%），其中男性21例，女性9例。骨与软组织肉瘤患者的诊断中位年龄为73.5岁（范围为7 - 83岁）。有22例患者为双癌，5例、2例和1例患者分别为三癌、四癌和五癌。结直肠癌是最常见的原发性癌症（n = 9）。总体而言，28.6%的患者为同时性癌症，而71.4%的患者为异时性癌症。所有患者的总体5年生存率为75.6%。骨与软组织肉瘤双癌患者的预后不一定很差。然而，有必要注意继发性恶性肿瘤的可能性。因此，在选择治疗方式时必须谨慎且组织有序，并对患有持续性多原发性恶性肿瘤的患者采取合理的护理方法。
