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终末期慢性肾病患者口腔健康状况及炎症标志物评估:一项横断面研究。

Assessment of oral health status and inflammatory markers in end stage chronic kidney disease patients: A cross-sectional study.

作者信息

Sharma Lokesh, Pradhan Devina, Srivastava Rahul, Shukla Manas, Singh Omveer

机构信息

Dental Surgeon and Consultant- Kanpur, Uttar Pradesh, India.

Department of Public Health Dentistry, Rama Dental College Hospital and Research Centre, Kanpur, Uttar Pradesh, India.

出版信息

J Family Med Prim Care. 2020 May 31;9(5):2264-2268. doi: 10.4103/jfmpc.jfmpc_101_20. eCollection 2020 May.

Abstract

AIM

To assess the oral health status and inflammatory markers in end stage chronic kidney disease (CKD) patients.

OBJECTIVES

To study and compare oral health status of end stage CKD patients with the control group (matched health individuals) and to study and compare inflammatory biomarkers in study and control groups.

MATERIALS AND METHODS

A cross-sectional study was conducted among 50 patients of end stage CKD and 50 matched healthy individual, who were taken as control in the study. Convenience sampling technique was used. Oral health status was recorded by using WHO proforma (2013). Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP ) were also measured in the both groups. These are inflammatory markers which show systemic inflammation. Statistical analysis was done by using IBM SPSS Statistics-version 21 (IBM Corp. Released 2012. IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.).

RESULTS

The study revealed that patients on dialysis going for transplantation have evidence of increased inflammation as indicated by raised CR values.

CONCLUSION

The present study concludes that the oral hygiene of the patients is deteriorated who are having chronic kidney disease. Good oral and dental care in CKD patients can improve the transplant outcomes.

摘要

目的

评估终末期慢性肾脏病(CKD)患者的口腔健康状况和炎症标志物。

目标

研究并比较终末期CKD患者与对照组(健康对照个体)的口腔健康状况,以及研究并比较研究组和对照组中的炎症生物标志物。

材料与方法

对50例终末期CKD患者和50例匹配的健康个体进行了一项横断面研究,后者作为研究中的对照。采用便利抽样技术。使用WHO表格(2013年版)记录口腔健康状况。两组均测量了红细胞沉降率(ESR)和C反应蛋白(CRP)。这些是显示全身炎症的炎症标志物。使用IBM SPSS Statistics 21版软件(IBM公司。2012年发布。适用于Windows的IBM SPSS Statistics,版本21.0。纽约州阿蒙克:IBM公司)进行统计分析。

结果

研究表明,准备进行移植的透析患者存在炎症增加的迹象,表现为CR值升高。

结论

本研究得出结论,慢性肾脏病患者的口腔卫生状况恶化。对CKD患者进行良好的口腔和牙齿护理可改善移植结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ef/7380786/80be03bb88b9/JFMPC-9-2264-g001.jpg

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