Duseja Ajay, Chahal Gurparkash Singh, Jain Ashish, Mehta Manu, Ranjan Aditya, Grover Vishakha
Department of Hepatology, PGIMER, Panjab University, Chandigarh, India.
Department of Periodontology, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India.
J Indian Soc Periodontol. 2021 Jan-Feb;25(1):47-54. doi: 10.4103/jisp.jisp_45_20. Epub 2020 Sep 21.
Recent evidence suggests an interconnection between chronic periodontal disease and systemic diseases.
The aim of this study is to evaluate the possible association between nonalcoholic fatty liver disease (NAFLD) and inflammatory periodontal disease among north Indian population.
Tertiary health care center, cross-sectional case-control observational study.
A total of 40 cases, i.e., patients with NAFLD and 40 healthy volunteers were included over a period of 8 months and their periodontal status was compared. The status of their hepatic health was ascertained by anthropometric, imaging, and biochemical evaluation including ultrasound examination of abdomen and transient elastography.
Paired -test, multivariate logistic regression analysis using IBM SPSS STATISTICS (version 22.0, Armonk, NY: IBM Corp).
The study revealed that only 11.9% and 20% of participants had periodontitis, in healthy controls and hepatic disease patients, respectively. A statistically significant difference was observed in clinical parameters of periodontal status, except for malocclusion. Comparative analysis of tumor necrosis factor-α (TNF-α), interleukin-6, C-reactive protein, and cytokeratin-18 revealed differences in mean scores, though statistically nonsignificant. Only aspartate transaminase, number of missing teeth, and bleeding on probing (BOP) were observed with higher odds ratios for hepatic disease patients. Spearman correlation analysis revealed significant positive correlations between TNF-α and BOP, for cases.
Patients with hepatic disease showed a higher prevalence of periodontal disease, worse oral hygiene and periodontal health status compared to healthy individuals.
近期证据表明慢性牙周病与全身性疾病之间存在关联。
本研究旨在评估印度北部人群中非酒精性脂肪性肝病（NAFLD）与炎症性牙周病之间可能存在的关联。
三级医疗保健中心，横断面病例对照观察性研究。
在8个月的时间里，共纳入40例NAFLD患者及40名健康志愿者，并比较他们的牙周状况。通过人体测量、影像学和生化评估（包括腹部超声检查和瞬时弹性成像）确定他们的肝脏健康状况。
采用配对t检验，使用IBM SPSS STATISTICS（版本22.0，纽约州阿蒙克：IBM公司）进行多因素逻辑回归分析。
研究显示，健康对照组和肝病患者中分别仅有11.9%和20%的参与者患有牙周炎。除错牙合外，牙周状况的临床参数存在统计学显著差异。肿瘤坏死因子-α（TNF-α）、白细胞介素-6、C反应蛋白和细胞角蛋白-18的比较分析显示平均得分存在差异，尽管无统计学意义。仅观察到肝病患者的天冬氨酸转氨酶、缺失牙数量和探诊出血（BOP）的优势比更高。Spearman相关性分析显示，病例组中TNF-α与BOP之间存在显著正相关。
与健康个体相比，肝病患者的牙周病患病率更高，口腔卫生和牙周健康状况更差。
