循环肿瘤细胞和播散肿瘤细胞在胰腺癌中的重要性。

Hasanain Alina, Blanco Barbara Aldana, Yu Jun, Wolfgang Christopher L

Department of Surgery, Division of Surgical Oncology, Johns Hopkins University, Baltimore, MD 21287.

The Johns Hopkins Pancreatic Cancer Precision Medicine Program.

Surg Open Sci. 2019 Nov 8;1(2):49-55. doi: 10.1016/j.sopen.2019.08.002. eCollection 2019 Oct.

Pancreatic cancer is a lethal disease in a large part due to the systemic nature at the time of diagnosis. In those patients who undergo a potentially curative resection of pancreatic cancer, the overwhelming majority will have systemic relapse. Circulating tumor cells are an important mediator of the development of metastases. Circulating tumor cells have been identified in patients with clinically localized resectable pancreatic cancer and exist as several phenotypes. Mesenchymal and stem cell-like phenotypes of circulating tumor cells predict early recurrence and worse survival. This review focuses on the current understanding of circulating tumor cells in pancreatic cancer and how this information can be used in developing more effective therapy in the future.

胰腺癌是一种致命疾病，很大程度上是由于其在诊断时就具有全身性。在那些接受了可能治愈性胰腺癌切除术的患者中，绝大多数会出现全身复发。循环肿瘤细胞是转移发生的重要介导因素。在临床局限性可切除胰腺癌患者中已发现循环肿瘤细胞，并且存在多种表型。循环肿瘤细胞的间充质和干细胞样表型预示着早期复发和较差的生存率。本综述重点关注目前对胰腺癌中循环肿瘤细胞的认识，以及这些信息如何用于未来开发更有效的治疗方法。