Takasaki N, Kaneko Y, Maseki N, Sakurai M
Department of Cancer Chemotherapy, Saitama Cancer Center, Japan.
Cancer Genet Cytogenet. 1988 Jan;30(1):109-17. doi: 10.1016/0165-4608(88)90098-2.
Two cases of chronic myelomonocytic leukemia (CMMoL) with trisomy 11 as the sole chromosome abnormality are reported. A simple trisomy 11 also has been reported in 11 patients with myeloproliferative disorders, including CMMoL and acute nonlymphocytic leukemia (ANLL) in the literature. From data on these 13 patients, leukemia with trisomy 11 may be characterized by a nonlymphoid origin and myelomonocytic features. Patients with this abnormality were mostly elderly, and often had a preleukemic phase and a short survival. We propose that trisomy 11 and nonlymphocytic leukemia with myelomonocytic features may be a new association in human neoplasia.
报告了2例仅以11号染色体三体为唯一染色体异常的慢性粒单核细胞白血病（CMMoL）。文献中也报道了11例骨髓增殖性疾病患者存在单纯11号染色体三体，这些疾病包括CMMoL和急性非淋巴细胞白血病（ANLL）。根据这13例患者的数据，11号染色体三体的白血病可能具有非淋巴细胞起源和粒单核细胞特征。有这种异常的患者大多为老年人，常经历白血病前期且生存期短。我们提出11号染色体三体与具有粒单核细胞特征的非淋巴细胞白血病可能是人类肿瘤形成中的一种新关联。
