Sandberg A A, Morgan R, Sait S N, Berger R, Flandrin G, Schrier S, Hecht F
Cancer Genet Cytogenet. 1987 May;26(1):117-25. doi: 10.1016/0165-4608(87)90139-7.
Trisomy 4 is a newly recognized primary chromosome change in leukemia. Five cases of acute nonlymphocytic leukemia (ANLL) are described from the United States and France. As in cases from Belgium, the only chromosome abnormality detected in the leukemic cells was trisomy 4. This was associated preferentially with ANLL of the M4 type (by FAB classification): acute myelomonocytic leukemia.
4号染色体三体是白血病中一种新发现的原发性染色体改变。本文描述了来自美国和法国的5例急性非淋巴细胞白血病（ANLL）。与比利时的病例一样，在白血病细胞中检测到的唯一染色体异常是4号染色体三体。这一异常优先与M4型（根据FAB分类）ANLL相关：急性粒单核细胞白血病。
