Clinic of Nephrology, Hypertension, Diabetes and Endocrinology, Health Campus Immunology, Infectiology and Inflammation, Otto-von Guericke University, Magdeburg, Germany.
Nephrology Section, Hannover Medical School, Hannover, Germany.
J Diabetes. 2020 Nov;12(11):856-859. doi: 10.1111/1753-0407.13102. Epub 2020 Sep 4.
Highlights In normoalbuminuric diabetic patients at low cardiovascular risk, the risk of transition from normo- to microalbuminuria is lower in women, despite the nonprotective effects of the angiotensin receptor blocker olmesartan. Additional methods of assessment of albuminuria in clinical studies (eg, measurements of albumin and creatinine excretion rate) should be implemented or the actually accepted higher urine albumin creatinine ratio (UACR) cutoff values for microalbuminuria in women reconsidered.
要点 在心血管风险较低的白蛋白正常的糖尿病患者中，尽管血管紧张素受体阻滞剂奥美沙坦没有保护作用，但女性从白蛋白正常到微量白蛋白尿的转变风险较低。在临床研究中应采用其他方法评估白蛋白尿（例如，白蛋白和肌酐排泄率的测量），或者重新考虑女性微量白蛋白尿中实际接受的较高尿白蛋白肌酐比值（UACR）截断值。
