Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru.
Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru.
Diabetes Metab Syndr. 2020 Sep-Oct;14(5):1339-1345. doi: 10.1016/j.dsx.2020.07.018. Epub 2020 Jul 17.
Short stature has been linked with the development of metabolic syndrome (MetS). However, only one study has been conducted in Latin American adults. We aimed to assess the association between short stature and MetS in workers of a private educational institution in Peru. In addition, we evaluated the association between height and surrogate markers of insulin resistance (IR).
We performed an analytical cross-sectional study. We categorized the height in tertiles and evaluated MetS according to the Latin American Diabetes Association statement. We used the triglycerides and glucose (TyG) index and the triglycerides to HDL-cholesterol (TG/HDL-c) ratio as IR markers. We elaborated crude and adjusted Poisson generalized linear models to evaluate the association between height tertiles and MetS. For the IR markers, we carried out crude and adjusted linear regressions.
We analyzed 1080 participants and the overall prevalence of MetS was 16.2%. In the adjusted Poisson generalized linear model, using the high tertile as a reference, we found statistically significant differences in the prevalence of MetS with the low and intermediate tertile (aPR = 2.03; 95%CI: 1.48-2.77 and aPR = 1.41; 95%CI: 1.01-1.99; respectively). In the gender-stratified analysis, we found statistical significance between height and MetS when comparing high and low tertile for both genders. For IR markers, we found an inverse association between the height and TyG index (aβ = -0.14; 95%CI: 0.19 to -0.10) and TG/HDL-c ratio (aβ = -0.62; 95%CI: 0.84 to -0.39). When we stratified by gender, the association for both secondary outcomes and height remained statistically significant in both groups.
We found an association between short stature and the prevalence of MetS and IR markers. We need studies with national representative samples to define the threshold of short stature with better sensitivity and specificity for the screening of MetS.
身材矮小与代谢综合征（MetS）的发生有关。然而，仅有一项针对拉丁美洲成年人的研究对此进行了探讨。我们旨在评估秘鲁某私立教育机构工作人员中身材矮小与 MetS 的相关性，并评估身高与胰岛素抵抗（IR）替代标志物之间的相关性。
我们进行了一项分析性横断面研究。我们将身高分为三分位，并根据拉丁美洲糖尿病协会的标准评估 MetS。我们使用甘油三酯和葡萄糖（TyG）指数以及甘油三酯与高密度脂蛋白胆固醇（TG/HDL-c）比值作为 IR 标志物。我们构建了未经调整和调整后的泊松广义线性模型，以评估身高三分位与 MetS 的相关性。对于 IR 标志物，我们进行了未经调整和调整后的线性回归。
我们共分析了 1080 名参与者，MetS 的总体患病率为 16.2%。在调整后的泊松广义线性模型中，以高三分位为参考，我们发现低三分位和中三分位的 MetS 患病率存在统计学差异（调整后的患病率比[aPR]为 2.03；95%CI：1.48-2.77 和 aPR 为 1.41；95%CI：1.01-1.99）。在性别分层分析中，我们发现两性比较时，高三分位与 MetS 之间存在统计学差异。对于 IR 标志物，我们发现身高与 TyG 指数（aβ=-0.14；95%CI：0.19 至-0.10）和 TG/HDL-c 比值（aβ=-0.62；95%CI：0.84 至-0.39）之间存在负相关。当我们按性别分层时，两组的次要结局和身高之间的相关性仍然具有统计学意义。
我们发现身材矮小与 MetS 和 IR 标志物的患病率之间存在相关性。我们需要具有全国代表性样本的研究来确定 MetS 筛查的身材矮小的最佳敏感性和特异性阈值。
